Betulonic acid: A review on its sources, biological activities, and molecular mechanisms

被引：0
|
作者：
Lou, Shengying [1 ]
Dai, Chunyan [2 ]
Wu, Yuhua [1 ]
Wang, Lijiang [1 ]
Jin, Yuancheng [1 ]
Shen, Naitao [1 ]
Lv, Wang [1 ]
Wu, Miaolian [1 ]
Xu, Xiaojun [1 ,4 ]
Han, Jichun [3 ]
Fan, Xiangcheng [1 ,4 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 4, Sch Med, Dept Pathol, Yiwu 322000, Peoples R China
[2] Zhejiang Univ, Affiliated Hosp 4, Dept Pathol, Sch Med, Yiwu 322000, Peoples R China
[3] Binzhou Med Univ, Coll Combine Tradit Chinese & Western Med, Yantai 264003, Peoples R China
[4] Zhejiang Univ, Int Inst Med, Ctr Innovat Tradit Chinese Med Target & New Drug R, Yiwu 322000, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2025年 / 998卷
基金：
中国国家自然科学基金;
关键词：
Betulonic acid; Lupane; Betulinic acid; Biological activities; Pentacyclic triterpenoids; BETULINIC ACID; ANTIVIRAL ACTIVITY; NATURAL-PRODUCTS; CYTOTOXIC ACTIVITY; PENTACYCLIC TRITERPENOIDS; ACETYLENIC DERIVATIVES; LUPANE TRITERPENOIDS; RECENT PROGRESS; IN-VIVO; INHIBITORS;
D O I：
10.1016/j.ejphar.2025.177518
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pentacyclic triterpenoids represent a significant class of phytochemicals, categorized into oleanane, ursane, friedelane, and lupane. Among these, betulonic acid stands out as a lupane-type pentacyclic triterpenoid found in numerous plants. Its diverse biological properties, including anti-tumor, anti-viral, anti-inflammatory, antibacterial, and hepato-protective effects, have been extensively documented. To further explore the therapeutic potential of betulonic acid and its derivatives, we provide a comprehensive review of their sources, biological activities, and molecular mechanisms. We aim for this synthesis of data to stimulate fresh perspectives on betulonic acid and its potential in drug discovery.
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页数：16
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