Betulonic acid: A review on its sources, biological activities, and molecular mechanisms

被引：0

作者：

Lou, Shengying ^{[1
]}

Dai, Chunyan ^{[2
]}

Wu, Yuhua ^{[1
]}

Wang, Lijiang ^{[1
]}

Jin, Yuancheng ^{[1
]}

Shen, Naitao ^{[1
]}

Lv, Wang ^{[1
]}

Wu, Miaolian ^{[1
]}

Xu, Xiaojun ^{[1
,4
]}

Han, Jichun ^{[3
]}

Fan, Xiangcheng ^{[1
,4
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 4, Sch Med, Dept Pathol, Yiwu 322000, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 4, Dept Pathol, Sch Med, Yiwu 322000, Peoples R China

[3] Binzhou Med Univ, Coll Combine Tradit Chinese & Western Med, Yantai 264003, Peoples R China

[4] Zhejiang Univ, Int Inst Med, Ctr Innovat Tradit Chinese Med Target & New Drug R, Yiwu 322000, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2025年 / 998卷

基金：

中国国家自然科学基金;

关键词：

Betulonic acid; Lupane; Betulinic acid; Biological activities; Pentacyclic triterpenoids; BETULINIC ACID; ANTIVIRAL ACTIVITY; NATURAL-PRODUCTS; CYTOTOXIC ACTIVITY; PENTACYCLIC TRITERPENOIDS; ACETYLENIC DERIVATIVES; LUPANE TRITERPENOIDS; RECENT PROGRESS; IN-VIVO; INHIBITORS;

D O I：

10.1016/j.ejphar.2025.177518

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pentacyclic triterpenoids represent a significant class of phytochemicals, categorized into oleanane, ursane, friedelane, and lupane. Among these, betulonic acid stands out as a lupane-type pentacyclic triterpenoid found in numerous plants. Its diverse biological properties, including anti-tumor, anti-viral, anti-inflammatory, antibacterial, and hepato-protective effects, have been extensively documented. To further explore the therapeutic potential of betulonic acid and its derivatives, we provide a comprehensive review of their sources, biological activities, and molecular mechanisms. We aim for this synthesis of data to stimulate fresh perspectives on betulonic acid and its potential in drug discovery.

引用

页数：16

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