Plasma phosphorylated tau181 outperforms [18F] fluorodeoxyglucose positron emission tomography in the identification of early Alzheimer disease

被引：0

作者：

Quispialaya, Kely Monica ^{[1
,2
,3
]}

Therriault, Joseph ^{[1
,2
,4
]}

Aliaga, Antonio ^{[1
,3
,5
]}

Tissot, Cecile ^{[1
,2
,4
]}

Servaes, Stijn ^{[1
,2
,4
]}

Rahmouni, Nesrine ^{[1
,2
,4
]}

Karikari, Thomas K. ^{[6
,7
]}

Benedet, Andrea L. ^{[1
,6
]}

Ashton, Nicholas J. ^{[6
,8
]}

Macedo, Arthur C. ^{[1
,2
,4
]}

Lussier, Firoza Z. ^{[1
,7
]}

Stevenson, Jenna ^{[1
]}

Wang, Yi-Ting ^{[1
,2
,4
]}

Arias, Jaime Fernandez ^{[1
,2
,4
]}

Hosseini, Ali ^{[1
,2
,4
]}

Matsudaira, Takashi ^{[9
,10
]}

Jean-Claude, Bertrand ^{[3
]}

Gilfix, Brian M. ^{[11
]}

Zimmer, Eduardo R. ^{[1
,5
,12
,13
]}

Soucy, Jean-Paul ^{[2
]}

Pascoal, Tharick A. ^{[7
]}

Gauthier, Serge ^{[1
,4
,14
]}

Zetterberg, Henrik ^{[6
,15
,16
,17
,18
,19
]}

Blennow, Kaj ^{[6
,15
]}

Rosa-Neto, Pedro ^{[1
,2
,3
,4
,14
]}

机构：

[1] McGill Univ, Translat Neuroimaging Lab, Res Ctr Studies Aging, Douglas Hosp, Montreal, PQ, Canada

[2] Montreal Neurol Inst, Montreal, PQ, Canada

[3] McGill Univ, Dept Expt Med, Montreal, PQ, Canada

[4] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[5] Univ Fed Rio Grande do Sul, Dept Pharmacol, Grad Program Biol Sci Biochem PPGBioq & Pharmacol, Porto Alegre, Brazil

[6] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Dept Psychiat & Neurochem, Molndal, Sweden

[7] Univ Pittsburgh, Sch Med, Dept Neurol & Psychiat, Pittsburgh, PA USA

[8] Univ Gothenburg, Wallenberg Ctr Mol Med, Gothenburg, Sweden

[9] Hamamatsu Univ Sch Med, Dept Biofunct Imaging, Hamamatsu, Japan

[10] Natl Hosp Org, Shizuoka Inst Epilepsy & Neurol Disorders, Dept Neurol, Urushiyama, Japan

[11] McGill Univ, Dept Specialized Med, Montreal, PQ, Canada

[12] Univ Fed Rio Grande do Sul, Dept Pharmacol, Porto Alegre, Brazil

[13] Pontificia Univ Catolica, Brain Inst Rio Grande Do Sul, Porto Alegre, RS, Brazil

[14] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[15] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[16] UCL, Inst Neurol, Dept Neurodegenerat Dis, London, England

[17] UCL, UK Dementia Res Inst, London, England

[18] Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

[19] Univ Wisconsin Madison, Wisconsin Alzheimers Dis Res Ctr, Sch Med & Publ Hlth, Madison, WI USA

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2024年 / 31卷 / 12期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

F-18]florbetapir-PET; F-18]FDG-PET; Alzheimer disease; cerebrospinal fluid; plasma p-tau181; CLINICAL-DIAGNOSIS; NATIONAL INSTITUTE; TASK-FORCE; BIOMARKER; ASSOCIATION; PET;

D O I：

10.1111/ene.16255

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose: This study was undertaken to compare the performance of plasma p-tau181 with that of [F-18]fluorodeoxyglucose (FDG) positron emission tomography (PET) in the identification of early biological Alzheimer disease (AD). Methods: We included 533 cognitively impaired participants from the Alzheimer's Disease Neuroimaging Initiative. Participants underwent PET scans, biofluid collection, and cognitive tests. Receiver operating characteristic analyses were used to determine the diagnostic accuracy of plasma p-tau181 and [F-18]FDG-PET using clinical diagnosis and core AD biomarkers ([F-18]florbetapir-PET and cerebrospinal fluid [CSF] p-tau181) as reference standards. Differences in the diagnostic accuracy between plasma p-tau181 and [F-18]FDG-PET were determined by bootstrap-based tests. Correlations of [F-18]FDG-PET and plasma p-tau181 with CSF p-tau181, amyloid beta (A beta) PET, and cognitive performance were evaluated to compare associations between measurements. Results: We observed that both plasma p-tau181 and [F-18]FDG-PET identified individuals with positive AD biomarkers in CSF or on A beta-PET. In the MCI group, plasma p-tau181 outperformed [F-18]FDG-PET in identifying AD measured by CSF (p = 0.0007) and by A beta-PET (p = 0.001). We also observed that both plasma p-tau181 and [F-18]FDG-PET metabolism were associated with core AD biomarkers. However, [F-18]FDG-PET uptake was more closely associated with cognitive outcomes (Montreal Cognitive Assessment, Mini-Mental State Examination, Clinical Dementia Rating Sum of Boxes, and logical memory delayed recall, p < 0.001) than plasma p-tau181. Conclusions: Overall, although both plasma p-tau181 and [F-18]FDG-PET were associated with core AD biomarkers, plasma p-tau181 outperformed [F-18]FDG-PET in identifying individuals with early AD pathophysiology. Taken together, our study suggests that plasma p-tau181 may aid in detecting individuals with underlying early AD.

引用

页数：12

共 45 条

[1] Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays [J].

Ashton, Nicholas J. ;

Puig-Pijoan, Albert ;

Mila-Aloma, Marta ;

Fernandez-Lebrero, Aida ;

Garcia-Escobar, Greta ;

Gonzalez-Ortiz, Fernando ;

Kac, Przemyslaw R. ;

Brum, Wagner S. ;

Benedet, Andrea L. ;

Lantero-Rodriguez, Juan ;

Day, Theresa A. ;

Vanbrabant, Jeroen ;

Stoops, Erik ;

Vanmechelen, Eugeen ;

Triana-Baltzer, Gallen ;

Moughadam, Setareh ;

Kolb, Hartmuth ;

Ortiz-Romero, Paula ;

Karikari, Thomas K. ;

Minguillon, Carolina ;

Sanchez, Juan Jose Hernandez ;

Navalpotro-Gomez, Irene ;

Grau-Rivera, Oriol ;

Manero, Rosa Maria ;

Puente-Periz, Victor ;

de la Torre, Rafael ;

Roquer, Jaume ;

Dage, Jeff L. ;

Zetterberg, Henrik ;

Blennow, Kaj ;

Suarez-Calvet, Marc .

ALZHEIMERS & DEMENTIA, 2023, 19 (05) :1913-1924

[2] Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease [J].

Bateman, Randall J. ;

Xiong, Chengjie ;

Benzinger, Tammie L. S. ;

Fagan, Anne M. ;

Goate, Alison ;

Fox, Nick C. ;

Marcus, Daniel S. ;

Cairns, Nigel J. ;

Xie, Xianyun ;

Blazey, Tyler M. ;

Holtzman, David M. ;

Santacruz, Anna ;

Buckles, Virginia ;

Oliver, Angela ;

Moulder, Krista ;

Aisen, Paul S. ;

Ghetti, Bernardino ;

Klunk, William E. ;

McDade, Eric ;

Martins, Ralph N. ;

Masters, Colin L. ;

Mayeux, Richard ;

Ringman, John M. ;

Rossor, Martin N. ;

Schofield, Peter R. ;

Sperling, Reisa A. ;

Salloway, Stephen ;

Morris, John C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (09) :795-804

[3] Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010 [J].

Beach, Thomas G. ;

Monsell, Sarah E. ;

Phillips, Leslie E. ;

Kukull, Walter .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2012, 71 (04) :266-273

[4] Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of β-amyloid (1-42) in human cerebrospinal fluid [J].

Bittner, Tobias ;

Zetterberg, Henrik ;

Teunissen, Charlotte E. ;

Ostlund, Richard E., Jr. ;

Militello, Michael ;

Andreasson, Ulf ;

Hubeek, Isabelle ;

Gibson, David ;

Chu, David C. ;

Eichenlaub, Udo ;

Heiss, Peter ;

Kobold, Uwe ;

Leinenbach, Andreas ;

Madin, Kairat ;

Manuilova, Ekaterina ;

Rabe, Christina ;

Blennow, Kaj .

ALZHEIMERS & DEMENTIA, 2016, 12 (05) :517-526

[5]

Cummings J, 2022, ALZHEIMERS DEMENT, V18, P531, DOI [10.1002/alz.12444, 10.14283/jpad.2021.41]

[6] COMPARING THE AREAS UNDER 2 OR MORE CORRELATED RECEIVER OPERATING CHARACTERISTIC CURVES - A NONPARAMETRIC APPROACH [J].

DELONG, ER ;

DELONG, DM ;

CLARKEPEARSON, DI .

BIOMETRICS, 1988, 44 (03) :837-845

[7]

DIEDENHOFEN B, 2015, PLOS ONE, V10, DOI [DOI 10.1371/JOURNAL.PONE.0121945, 10.1371/journal.pone.0121945]

[8] Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease [J].

Ewers, Michael ;

Insel, Philip S. ;

Stern, Yaakov ;

Weiner, Michael W. .

NEUROLOGY, 2013, 80 (13) :1194-1201

[9] The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease [J].

Hansson, Oskar ;

Edelmayer, Rebecca M. ;

Boxer, Adam L. ;

Carrillo, Maria C. ;

Mielke, Michelle M. ;

Rabinovici, Gil D. ;

Salloway, Stephen ;

Sperling, Reisa ;

Zetterberg, Henrik ;

Teunissen, Charlotte E. .

ALZHEIMERS & DEMENTIA, 2022, 18 (12) :2669-2686

[10] Biomarkers for neurodegenerative diseases [J].

Hansson, Oskar .

NATURE MEDICINE, 2021, 27 (06) :954-963

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