Evaluation of serum human epididymis protein 4 in children with chronic liver diseases

被引:1
作者
Mohamed, Nashwa Farouk [1 ]
Ali Behairy, Ola Galal [1 ]
El Defrawy, Manal Sadek [1 ]
Elsheraki, Samar Ahmed Mohamed [1 ]
Khashaba, Rana Atef [2 ]
机构
[1] Benha Univ, Fac Med, Pediat Dept, Banha 13511, Qalubia, Egypt
[2] Benha Univ, Fac Med, Clin & Chem Pathol Dept, Banha, Egypt
关键词
Chronic liver disease; HE4; liver fibrosis; non-invasive biomarker; pediatric liver disease;
D O I
10.1080/00365513.2024.2437612
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
The aim of this study was to evaluate the role of serum human epididymis protein 4 (HE4) as a non-invasive biomarker for the diagnosis of liver fibrosis in children with chronic liver diseases (CLD). This case-control study was conducted at Benha University Hospital, Egypt, involving 60 children with CLD and 60 healthy children as a control group. HE4 levels were measured by ELISA and compared with liver biopsy results. The CLD group had significant higher HE4 (median: 110.7, IQR: 96.7-120.4 pmol/L) compared to control group (median 42.07, IQR: 41.67-43.05 pmol/L), p < .001. HE4 levels increased significantly with the degree of fibrosis and histological activity index. At a cutoff point >48.3 pmol/L, HE4 diagnosed cases with mild fibrosis with a sensitivity of 95% and specificity of 91.3%. At a cutoff point >144.3 pmol/L, HE4 diagnosed cases with severe fibrosis with a sensitivity of 98% and specificity of 93.1%. Serum HE4 is a potential non-invasive marker for detecting liver fibrosis and its severity in children with CLD.
引用
收藏
页码:515 / 520
页数:6
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