Effects of cannabis use on the heart

被引:0
作者
Sharkova, Julia [1 ,2 ]
Nickolaus, Tanja [1 ,2 ]
Schaefer, Juergen R. [1 ,2 ]
机构
[1] UKGM Marburg, Ctr Unrecognized & Rare Dis ZusE, Ctr Internal Med, Clin Cardiol Angiol & Intens Care Med, Baldinger Str 1, D-35033 Marburg, Germany
[2] Philipps Univ Marburg, Baldinger Str 1, D-35033 Marburg, Germany
关键词
Marijuana; Tetrahydrocannabinol; Undesired side effects; Cardiac rhythm; Myocardial infarction; Marihuana; Unerw & uuml; nschte Nebenwirkungen; Herzrhythmus; Herzinfarkt; MYOCARDIAL-INFARCTION; MARIJUANA;
D O I
10.1007/s00059-024-05282-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cannabis and the marijuana derived from it, which mainly contains the psychoactive ingredient tetrahydrocannabinol (THC), is increasingly being used both for medicinal purposes and as a narcotic. While many emphasize the positive aspects and uses of cannabis, it is equally important to examine the potential negative effects on health. Here, we pay special attention to undesired cardiovascular effects, as the cardiovascular system is known to react strongly to psychoactive substances. This article highlights the current scientific findings on the effects of cannabis and marijuana on the heart and cardiovascular system. Since many patients conceal their marijuana consumption, we expect a high number of unreported cases. Therefore, the need to disclose any drug consumption is crucial for further therapeutic decisions when taking the medical history. Cannabis und das daraus gewonnene Marihuana, welches & uuml;berwiegend den psychoaktiven Wirkstoff Tetrahydrocannabinol (THC) enth & auml;lt, wird zunehmend zu medizinischen Zwecken, aber auch als Rauschmittel benutzt. W & auml;hrend Viele die positiven Aspekte und Verwendungsm & ouml;glichkeiten von Cannabis betonen, ist es ebenso wichtig, die m & ouml;glichen negativen Auswirkungen auf die Gesundheit zu beachten. Besonderes Augenmerk soll hier auf unerw & uuml;nschte kardiovaskul & auml;re Wirkungen gelegt werden, da das Herz-Kreislauf-System stark auf psychoaktive Substanzen reagieren kann. Im vorliegenden Artikel werden die aktuellen wissenschaftlichen Erkenntnisse zu den Auswirkungen von Cannabis sowie Marihuana auf das Herz und das Herz-Kreislauf-System beleuchtet. Da viele Patienten ihren Marihuanakonsum verheimlichen, ist von einer hohen Dunkelziffer auszugehen. Daher sollte bei der Erhebung der Anamnese auf die Bedeutung der ehrlichen Offenlegung eines m & ouml;glichen Drogenkonsums f & uuml;r die weiteren therapeutischen Schritte hingewiesen werden.
引用
收藏
页码:420 / 427
页数:8
相关论文
共 31 条
[1]   Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse [J].
Allen, JH ;
de Moore, GM ;
Heddle, R ;
Twartz, JC .
GUT, 2004, 53 (11) :1566-1570
[2]  
[Anonymous], 2017, The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research
[3]  
[Anonymous], 2018, FDA News
[4]   Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants [J].
Bansal, Sumit ;
Zamarripa, C. Austin ;
Spindle, Tory R. ;
Weerts, Elise M. ;
Thummel, Kenneth E. ;
Vandrey, Ryan ;
Paine, Mary F. ;
Unadkat, Jashvant D. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2023, 114 (03) :693-703
[5]   Interaction between warfarin and cannabis [J].
Damkier, Per ;
Lassen, Dorte ;
Christensen, Mette Marie Hougaard ;
Madsen, Kenneth Gronkjaer ;
Hellfritzsch, Maja ;
Pottegard, Anton .
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2019, 124 (01) :28-31
[6]  
fachinfo, Product information THC-CBD (Sativex)
[7]   DIMINISHED LIFETIME SUBSTANCE USE OVER TIME - AN INQUIRY INTO DIFFERENTIAL UNDERREPORTING [J].
FENDRICH, M ;
VAUGHN, CM .
PUBLIC OPINION QUARTERLY, 1994, 58 (01) :96-123
[8]   Multiwave analysis of retest artifact in the National Longitudinal Survey of Youth drug use [J].
Fendrich, M ;
Kim, JYS .
DRUG AND ALCOHOL DEPENDENCE, 2001, 62 (03) :239-253
[9]   Tolerance to Effects of High-Dose Oral 9-Tetrahydrocannabinol and Plasma Cannabinoid Concentrations in Male Daily Cannabis Smokers [J].
Gorelick, David A. ;
Goodwin, Robert S. ;
Schwilke, Eugene ;
Schwope, David M. ;
Darwin, William D. ;
Kelly, Deanna L. ;
McMahon, Robert P. ;
Liu, Fang ;
Ortemann-Renon, Catherine ;
Bonnet, Denis ;
Huestis, Marilyn A. .
JOURNAL OF ANALYTICAL TOXICOLOGY, 2013, 37 (01) :11-16
[10]   Delta-9-tetrahydrocannabinol (THC) serum concentrations and pharmacological effects in males after smoking a combination of tobacco and cannabis containing up to 69 mg THC [J].
Hunault, Claudine C. ;
Mensinga, Tjeert T. ;
de Vries, Irma ;
Kelholt-Dijkman, Hermien H. ;
Hoek, Jani ;
Kruidenier, Maaike ;
Leenders, Marianne E. C. ;
Meulenbelt, Jan .
PSYCHOPHARMACOLOGY, 2008, 201 (02) :171-181