Revisiting the GBB reaction and redefining its relevance in medicinal chemistry: A review

被引：1

作者：

Shukla, Pratibha ^{[1
]}

Azad, Chandra Sourabh ^{[2
]}

Deswal, Deepa ^{[1
]}

Narula, Anudeep Kumar ^{[1
]}

机构：

[1] Guru Gobind Singh Indraprastha Univ, Ctr Excellence Pharmaceut Sci CEPS, New Delhi 110078, India

[2] Texas A&M Univ, Dept Phys & Environm Sci, Corpus Christi, TX USA

来源：

DRUG DISCOVERY TODAY | 2024年 / 29卷 / 12期

关键词：

multicomponent reactions; GBB reaction; medicinal chemistry; antifungal agents; antimicrobial agen COVID-19 inhibitors ts; COVID-19; inhibitors; BLACKBURN-BIENAYME REACTION; MULTICOMPONENT REACTIONS; DERIVATIVES; DISCOVERY; DESIGN; SCAFFOLDS; DRUGS;

D O I：

10.1016/j.drudis.2024.104237

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Multicomponent reactions (MCRs) have significant relevance in the field of synthetic chemistry, and i recent times one of the MCR variants, named the Groebke-Blackburn-Bienaym & eacute; (GBB) reaction, h attracted massive attention for the synthesis of biologically important scaffolds. The present review elaborates on the chemical advancement reported for the GBB reaction with an emphasis on the role various catalytic systems. Further, the role of the GBB reaction has been redefined as a standard protocol for the synthesis of an array of potential bioactive compounds. n as of

引用

页数：9

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