Umpolung of N-Tosylhydrazones: Synthesis of N-Cyano Tosylhydrazones and Their [3,3]-Sigmatropic Rearrangement to 2-Aminoimidazoles

被引：1

作者：

Xia, Yiwen ^{[1
]}

Tang, Meng ^{[1
]}

机构：

[1] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 24期

基金：

中国国家自然科学基金;

关键词：

VERSATILE REAGENTS;

D O I：

10.1021/acs.joc.4c02580

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The umpolung of N-tosylhydrazones was reported for the first time. Synthesis of N-cyano tosylhydrazones was developed, and various N-cyano tosylhydrazones were prepared in good yields. An umpolung N-tosylhydrazones mechanism was proposed. Meanwhile, the [3,3]-sigmatropic rearrangement of N-cyano tosylhydrazones was examined, and the corresponding 2-aminoimidazoles were given.

引用

页码：18764 / 18768

页数：5

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