The Co-Occurrence of Medullary and Papillary Thyroid Carcinoma-A Literature Review Based on a Case Report

被引:0
作者
Nordhausen, Katharina [1 ]
Deutschbein, Timo [2 ,3 ]
Heinrichs, Volker [4 ]
Weyhe, Dirk [1 ]
Tabriz, Navid [1 ]
机构
[1] Carl von Ossietzky Univ Oldenburg, Pius Hosp Oldenburg, Univ Hosp Visceral Surg, Georgstr 12, D-26121 Oldenburg, Germany
[2] Medicover Oldenburg MVZ, Elisenstr 12, D-26122 Oldenburg, Germany
[3] Univ Wurzburg, Univ Hosp, Div Endocrinol & Diabet, Dept Internal Med 1, Josef Schneider Str 2, D-97080 Wurzburg, Germany
[4] Carl Von Ossietzky Univ Oldenburg, Pius Hosp Oldenburg, Div Nucl Med, Georgstr 12, D-26121 Oldenburg, Germany
关键词
BRAF V600E MUTATION; FINE-NEEDLE-ASPIRATION; CANCER; DIAGNOSIS; RET;
D O I
10.1155/2024/2393186
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The co-occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) is thought to be a rare phenomenon. Here, we present a patient undergoing surgery due to a suspected MTC. Histopathological workup confirmed the suspected diagnosis but also described an incidental PTC in the contralateral lobe with lymph node metastasis in the central cervical compartment. Case Presentation: A 58-year-old female presented with thyroid nodules and significantly elevated levels of calcitonin and carcinoembryonic antigen (CEA). She underwent total thyroidectomy along with central and bilateral lymph node dissection. Histology revealed a MTC of 20 mm and a BRAF V600E-positive PTC of 11 mm with central cervical lymph node metastasis. Postoperatively, ablative radioiodine therapy was performed. Two months later, both calcitonin and CEA were normalized. Conclusion: Simultaneous occurrence of MTC and PTC seems to be rare, but recent literature suggests that simultaneous occurrence is probably more frequent than initially thought. Preoperative calcitonin can be helpful in the diagnostic workup of thyroid nodules. Due to different treatment strategies, precise histological differentiation of potential lymph node metastasis is essential.
引用
收藏
页数:6
相关论文
共 28 条
  • [1] Synchronous occurrence of medullary and papillary thyroid cancer and survival rates
    Akgun, Elife
    Sager, Sait
    Beytur, Fatih
    Nazari, Azizullah
    Ozturk, Tulin
    Teksoz, Serkan
    Sonmezoglu, Kerim
    [J]. INDIAN JOURNAL OF CANCER, 2023, 60 (04) : 556 - 561
  • [2] Epidemiology of Simultaneous Medullary and Papillary Thyroid Carcinomas (MTC/PTC): An Italian Multicenter Study
    Appetecchia, Marialuisa
    Lauretta, Rosa
    Barnabei, Agnese
    Pieruzzi, Letizia
    Terrenato, Irene
    Cavedon, Elisabetta
    Mian, Caterina
    Castagna, Maria Grazia
    Elisei, Rossella
    Mariotti, Stefano
    Fugazzola, Laura
    Orlandi, Fabio
    Romei, Cristina
    Pani, Fabiana
    Calanchini, Matilde
    Loli, Paola
    Limone, Paolo
    Seregni, Ettore
    Durante, Cosimo
    Isidori, Andrea Maria
    Van Doorne, Dominique
    Fabbri, Andrea
    Filetti, Sebastiano
    Pacini, Furio
    Giacomelli, Luca
    [J]. CANCERS, 2019, 11 (10)
  • [3] Medullary and papillary tumors are frequently associated in the same thyroid gland without evidence of reciprocal influence in their biologic behavior
    Biscolla, RP
    Ugolini, C
    Sculli, M
    Bottici, V
    Castagna, MG
    Romei, C
    Cosci, B
    Molinaro, E
    Faviana, P
    Basolo, F
    Miccoli, P
    Pacini, F
    Pinchera, A
    Elisei, R
    [J]. THYROID, 2004, 14 (11) : 946 - 952
  • [4] Medullary thyroid carcinoma beyond surgery: advances, challenges, and perspectives
    Ceolin, Lucieli
    da Silveira Duval, Marta Amaro
    Benini, Antonio Felippe
    Ferreira, Carla Vaz
    Maia, Ana Luiza
    [J]. ENDOCRINE-RELATED CANCER, 2019, 26 (09) : R499 - R518
  • [5] Medullary thyroid carcinoma:: Pitfalls in diagnosis by fine needle aspiration cytology and relationship of cytomorphology to RET proto-oncogene mutations
    Chang, TC
    Wu, SL
    Hsiao, YL
    [J]. ACTA CYTOLOGICA, 2005, 49 (05) : 477 - 482
  • [6] Classical point mutations of RET, BRAF and RAS oncogenes are not shared in papillary and medullary thyroid cancer occurring simultaneously in the same gland
    Ciampi, R.
    Romei, C.
    Pieruzzi, L.
    Tacito, A.
    Molinaro, E.
    Agate, L.
    Bottici, V.
    Casella, F.
    Ugolini, C.
    Materazzi, G.
    Basolo, F.
    Elisei, R.
    [J]. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2017, 40 (01) : 55 - 62
  • [7] Deutsche Gesellschaft fur Allgemeinund Viszeralchirurgie eV (DGAV), S2k-Leitlinie Operative Therapie Benigner Schilddrusenerkrankungen, Aktualisierte Version vom 05.12.2021 Verfugbar Unter
  • [8] Surgical management of the lateral neck compartment for metastatic thyroid cancer
    Dralle, Henning
    Machens, Andreas
    [J]. CURRENT OPINION IN ONCOLOGY, 2013, 25 (01) : 20 - 26
  • [9] FINE NEEDLE ASPIRATION AND MEDULLARY THYROID CARCINOMA: THE RISK OF INADEQUATE PREOPERATIVE EVALUATION AND INITIAL SURGERY WHEN RELYING UPON FNAB CYTOLOGY ALONE
    Essig, Garth F., Jr.
    Porter, Kyle
    Schneider, David
    Debora, Arpaia
    Lindsey, Susan C.
    Busonero, Giulia
    Fineberg, Daniel
    Fruci, Barbara
    Boelaert, Kristien
    Smit, Johannes W.
    Meijer, Johannes Arnoldus Anthonius
    Duntas, Leonidas
    Sharma, Neil
    Costante, Giuseppe
    Filetti, Sebastiano
    Sippel, Rebecca S.
    Biondi, Bernadette
    Topliss, Duncan J.
    Pacini, Furio
    Maciel, Rui M. B.
    Walz, Patrick C.
    Kloos, Richard T.
    [J]. ENDOCRINE PRACTICE, 2013, 19 (06) : 920 - 927
  • [10] Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review
    Fallahi, Poupak
    Patrizio, Armando
    Stoppini, Giulio
    Elia, Giusy
    Ragusa, Francesca
    Paparo, Sabrina Rosaria
    Balestri, Eugenia
    Mazzi, Valeria
    Botrini, Chiara
    Varricchi, Gilda
    Ulisse, Salvatore
    Ghionzoli, Marco
    Antonelli, Alessandro
    Ferrari, Silvia Martina
    [J]. CURRENT ONCOLOGY, 2023, 30 (12) : 10237 - 10248