Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials

被引：0

作者：

Saadh, Mohamed J. ^{[1
]}

Kariem, Muthena ^{[2
,3
,4
]}

Shukla, Madhu ^{[5
]}

Ballal, Suhas ^{[6
]}

Kumar, Abhishek ^{[7
,8
]}

Chahar, Mamata ^{[9
]}

Saini, Suman ^{[10
]}

Kapila, Ish ^{[11
]}

Hasaanzadeh, Shirin ^{[12
]}

机构：

[1] Middle East Univ, Fac Pharm, Amman 11831, Jordan

[2] Islamic Univ, Med Lab Tech Coll, Dept Med Anal, Najaf, Iraq

[3] Islamic Univ Al Diwaniyah, Med Lab Tech Coll, Dept Med Anal, Al Diwaniyah, Iraq

[4] Islamic Univ Babylon, Med Lab Tech Coll, Dept Med Anal, Babylon, Iraq

[5] Marwadi Univ, Res Ctr, Fac Engn & Technol, Dept Comp Engn, Rajkot 360003, Gujarat, India

[6] JAIN Deemed Univ, Sch Sci, Dept Chem & Biochem, Bangalore, Karnataka, India

[7] Shobhit Univ, Adarsh Vijendra Inst Pharmaceut Sci, Sch Pharm, Gangoh 247341, Uttar Pradesh, India

[8] Arka Jain Univ, Dept Pharm, Jamshedpur 831001, Jharkhand, India

[9] NIMS Univ Rajasthan, NIMS Inst Engn & Technol, Dept Chem, Jaipur, India

[10] Chandigarh Engn Coll, Chandigarh Grp Coll Jhanjeri, Dept Appl Sci, Mohali 140307, Punjab, India

[11] Chitkara Univ, Inst Engn & Technol, Ctr Res Impact & Outcome, Rajpura 140401, Punjab, India

[12] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2024年 / 175卷

关键词：

Garlic; Blood pressure; Hypertension; Aged garlic extract; Meta-analysis; DISEASE; PROTEIN; LIVER; RATS; BIAS;

D O I：

10.1016/j.prostaglandins.2024.106914

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: There is no consensus based on the existing literature regarding the effect of aged garlic extract (AGE) on blood pressure. The present systematic review and meta-analysis was conducted to synthesize existing data from randomized clinical trials (RCTs) concerning the impact of AGE supplementation on blood pressure in hypertensive patients. Methods: We searched English web databases including, PubMed, Scopus, Embase, Web of Science until August 2024. Random-effects meta-analysis was used to pool weighted mean differences (WMD) and 95 % CI for the outcomes. Results: Overall, nine RCTs with584 participants met inclusion criteria. AGE tea supplementation reduces systolic blood pressure (SBP) (WMD: -4.03; %95CI: -6.87, -1.20; I2: 57.1 %) and diastolic blood pressure (DBP) (WMD: -1.44; 95 % CI= -2.87, -0.02; P = 0.052; I2: 36.8 %; P: 0.105). Moreover, subgroup analysis indicated that higher doses of AGE supplementation in hypertensive patients significantly decreased DBP, and SBP. Conclusion: The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day. To confirm these results, well-designed future trials will be needed.

引用

页数：7

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