The role of cGAS-STING in remodeling the tumor immune microenvironment induced by radiotherapy

被引：0
|
作者：
Jiang, Qingyu [1 ,2 ,3 ,4 ]
Chen, Zhiheng [5 ]
Jiang, Jin [5 ]
Chen, Qianping [1 ,3 ,4 ]
Lan, Huiyin [1 ,3 ,4 ]
Zhu, Ji [1 ,3 ,4 ]
Mao, Wei [1 ,3 ,4 ]
机构：
[1] Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou 310000, Zhejiang, Peoples R China
[2] Zhejiang Chinese Med Univ, Hangzhou 310053, Peoples R China
[3] Chinese Acad Sci, Hangzhou Inst Med HIM, Hangzhou 310000, Peoples R China
[4] Zhejiang Key Lab Radiat Oncol, Hangzhou 310000, Peoples R China
[5] Jiaxing Univ, Hosp Jiaxing 1, Affiliated Hosp, Dept Oncol, Jiaxing, Peoples R China
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2025年 / 209卷
基金：
中国国家自然科学基金;
关键词：
Radiotherapy; Tumor immune microenvironment; CGAS-STING pathway; DENDRITIC CELLS; RADIATION; CANCER; IMMUNOTHERAPY; PROMOTES; PATHWAY; OPPORTUNITIES; SURVIVAL; DEATH; IDO;
D O I：
10.1016/j.critrevonc.2025.104658
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The activation of the cGAS-STING pathway occurs when tumor cell DNA is damaged by ionizing radiation. Once triggered, this pathway reshapes the tumor immune microenvironment by promoting the maturation, activation, polarization, and immune-killing capacity of immune cells, as well as by inducing the release of interferons and the expression of immune-related genes. In addition, the gut microbiota and various mechanisms of programmed cell death interact with the cGAS-STING pathway, further influencing its function in remodeling the immune microenvironment after radiotherapy. Therefore, investigating the mechanisms of the cGAS-STING pathway in reshaping the tumor immune microenvironment post-radiotherapy can not only optimize the efficacy of combined radiotherapy and immunotherapy but also provide new research directions and potential targets for cancer treatment.
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页数：14
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