The role of cGAS-STING in remodeling the tumor immune microenvironment induced by radiotherapy

被引：0

作者：

Jiang, Qingyu ^{[1
,2
,3
,4
]}

Chen, Zhiheng ^{[5
]}

Jiang, Jin ^{[5
]}

Chen, Qianping ^{[1
,3
,4
]}

Lan, Huiyin ^{[1
,3
,4
]}

Zhu, Ji ^{[1
,3
,4
]}

Mao, Wei ^{[1
,3
,4
]}

机构：

[1] Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou 310000, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Hangzhou 310053, Peoples R China

[3] Chinese Acad Sci, Hangzhou Inst Med HIM, Hangzhou 310000, Peoples R China

[4] Zhejiang Key Lab Radiat Oncol, Hangzhou 310000, Peoples R China

[5] Jiaxing Univ, Hosp Jiaxing 1, Affiliated Hosp, Dept Oncol, Jiaxing, Peoples R China

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2025年 / 209卷

基金：

中国国家自然科学基金;

关键词：

Radiotherapy; Tumor immune microenvironment; CGAS-STING pathway; DENDRITIC CELLS; RADIATION; CANCER; IMMUNOTHERAPY; PROMOTES; PATHWAY; OPPORTUNITIES; SURVIVAL; DEATH; IDO;

D O I：

10.1016/j.critrevonc.2025.104658

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The activation of the cGAS-STING pathway occurs when tumor cell DNA is damaged by ionizing radiation. Once triggered, this pathway reshapes the tumor immune microenvironment by promoting the maturation, activation, polarization, and immune-killing capacity of immune cells, as well as by inducing the release of interferons and the expression of immune-related genes. In addition, the gut microbiota and various mechanisms of programmed cell death interact with the cGAS-STING pathway, further influencing its function in remodeling the immune microenvironment after radiotherapy. Therefore, investigating the mechanisms of the cGAS-STING pathway in reshaping the tumor immune microenvironment post-radiotherapy can not only optimize the efficacy of combined radiotherapy and immunotherapy but also provide new research directions and potential targets for cancer treatment.

引用

页数：14

共 50 条

[21] Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer
Yang, Chunsheng
Liang, Yan
Liu, Ning
Sun, Meili
RADIATION ONCOLOGY, 2023, 18 (01)
[22] The role of radiotherapy in reshaping tumor immune microenvironment
Hu, Xiaoyu
Zhao, Mengyu
Yue, Jinbo
FRONTIERS IN IMMUNOLOGY, 2023, 14
[23] Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer
Chunsheng Yang
Yan Liang
Ning Liu
Meili Sun
Radiation Oncology, 18
[24] The role of cGAS-STING signaling in the development and therapy of head and neck squamous cell carcinoma
Shao, Chengze
Chen, Jiawen
Qiang, Bi
Ye, Junmei
Yan, Fangrong
Zhu, Yongbo
FRONTIERS IN IMMUNOLOGY, 2024, 15
[25] Targeting cGAS-STING: modulating the immune landscape of hepatic diseases
Xue, Feng
Liu, Yong-Kang
Chen, Xiao-Ying
Chen, Shan-Shan
Yu, Xiang-Rong
Li, Hua-Wen
Lu, Li-Gong
Chen, Mu-He
FRONTIERS IN IMMUNOLOGY, 2025, 16
[26] The role of cGAS-STING signaling in ischemic stroke: From immune response to therapeutic targeting
Chauhan, Chandan
Kaundal, Ravinder Kumar
DRUG DISCOVERY TODAY, 2023, 28 (11)
[27] RECQL4 Inhibits Radiation-Induced Tumor Immune Awakening via Suppressing the cGAS-STING Pathway in Hepatocellular Carcinoma
Hong, Weifeng
Zhang, Yang
Wang, Siwei
Li, Zongjuan
Zheng, Danxue
Hsu, Shujung
Zhou, Jian
Fan, Jia
Chen, Zhesheng
Xia, Xiaojun
Zeng, Zhaochong
Gao, Qiang
Yu, Min
Du, Shisuo
ADVANCED SCIENCE, 2024, 11 (16)
[28] Targeting cGAS-STING pathway for reprogramming tumor-associated macrophages to enhance anti-tumor immunotherapy
Zhang, Weiyue
Huang, Xin
BIOMARKER RESEARCH, 2025, 13 (01)
[29] Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS-STING Pathway
Constanzo, Julie
Faget, Julien
Ursino, Chiara
Badie, Christophe
Pouget, Jean-Pierre
FRONTIERS IN IMMUNOLOGY, 2021, 12
[30] Nanoformulations of chemotherapeutic activators of the cGAS-STING pathway in tumor chemoimmunotherapy
Wang, Lingzhi
Yu, Zhuo
Zhang, Jihong
Guo, Jianfeng
DRUG DISCOVERY TODAY, 2024, 29 (03)

← 1 2 3 4 5 →