Copper-Catalyzed Radical Cascade Cyclization of N-Substituted Indole-3-Aldehydes with Aryl Alkenes: Access to Pyrrolo[1,2-a]indole Scaffolds

被引:0
|
作者
Cheng, Weibo [1 ]
Sun, Junzheng [1 ]
Liu, Changji [1 ]
Zhong, Yidong [2 ]
Xia, Chengcai [1 ]
Yang, Wenjing [1 ]
机构
[1] Shandong First Med Univ & Shandong Acad Med Sci, Pharm Coll, Jinan 250117, Peoples R China
[2] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Pharm, Jinan 250117, Peoples R China
来源
JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 03期
关键词
PROPARGYLINDOLES; ANNULATION; INDOLES;
D O I
10.1021/acs.joc.4c02755
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Herein, we report a Cu-DTBP-catalyzed [3 + 2] cycloaddition reaction between 1-(2-oxo-2-phenylethyl)-1H-indole-3-aldehyde and arylalkene, using DMF as the solvent. Under relatively mild reaction conditions, a series of indole compounds were synthesized in moderate yields (up to 73%). This protocol features good functional group tolerance and high atom economy. In addition, we synthesized a total of 20 target compounds, providing a reliable and straightforward method to obtain structurally diverse pyrrolo[1,2-a]indole derivatives.
引用
收藏
页码:1367 / 1375
页数:9
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