Outcomes of liver transplant for colorectal liver metastasis: a systematic review and meta-analysis

被引:0
作者
Dawood, Zaiba Shafik [1 ]
Brown, Zachary J. [2 ]
Munir, Muhammad Musaab [3 ,4 ]
Waqar, Usama [1 ]
Rawicz-Pruszynski, Karol [3 ,4 ]
Endo, Yutaka [3 ,4 ]
Gajjar, Aryan [3 ,4 ]
Schenk, Austin [5 ]
Pawlik, Timothy M. [3 ,4 ]
机构
[1] Aga Khan Univ Hosp, Med Coll, Karachi, Pakistan
[2] NYU, Long Isl Sch Med, Dept Surg, Mineola, NY USA
[3] Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH 43210 USA
[4] James Comprehens Canc Ctr, Columbus, OH 43210 USA
[5] Ohio State Univ, Dept Surg, Div Transplant, Wexner Med Ctr, Columbus, OH USA
关键词
Liver transplantation; Nonresectable colorectal liver metastasis; Survival outcomes; QUALITY-OF-LIFE; HEPATIC METASTASES; RANDOMIZED-TRIALS; CANCER; CHEMOTHERAPY; CONVERSION; RESECTION; SURVIVAL; HETEROGENEITY; SURGERY;
D O I
10.1016/j.gassur.2024.09.006
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Liver transplantation (LT) for nonresectable colorectal liver metastasis (NRCRLM) has become accepted for select patients meeting strict inclusion criteria. Advancements in patient selection and understanding of cancer biology may expand benefits to patients with colorectal liver metastasis (CRLM). In this meta-analysis, we sought to assess survival outcomes, recurrence patterns, and quality of life (QoL) after LT for CRLM. Methods: PubMed, Embase, and Scopus databases were searched. A random-effect meta-analysis was conducted to obtain pooled overall survival (OS) and disease-free survival (DFS) rates and to compare QoL from baseline. Continuous data were analyzed, and standardized mean differences were reported. Results: Overall, 16 studies (403 patients, 58.8% male sex) were included. The pooled 1-, 3-, and 5-year OS after LT for NRCRLM was 96% (95% CI: 92%-99%), 77% (95% CI: 62%-89%), and 53% (95% CI: 45%-61%), respectively. Moreover, the pooled 1-, 3-, and 5-year DFS was 58% (95% CI: 43%-72%), 33% (95% CI: 9%-61%), and 13% (95% CI: 4%-27%), respectively. Overall, 201 patients (49.8%) experienced recurrence during the follow-up period with the lungs being the most common site (45.8%). There was no significant differences in physical and emotional functioning, fatigue, and pain components of QoL at 6 months after LT compared with baseline (all P > .05). Conclusion: LT for NRCRLM demonstrated good OS outcomes with no differences in the QoL at 6 months after transplantation. Transplantation may represent a viable treatment option for NRCRLM. (c) 2024 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights are reserved, in
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页码:1943 / 1950
页数:8
相关论文
共 63 条
[1]  
Adam R, 2004, ANN SURG, V240, P644, DOI 10.1097/01.sla.0000141198.92114.16
[2]  
Adam R, 2024, J CLIN ONCOL, V42
[3]   Patients With Initially Unresectable Colorectal Liver Metastases: Is There a Possibility of Cure? [J].
Adam, Rene ;
Wicherts, Dennis A. ;
de Haas, Robbert J. ;
Ciacio, Oriana ;
Levi, Francis ;
Paule, Bernard ;
Ducreux, Michel ;
Azoulay, Daniel ;
Bismuth, Henri ;
Castaing, Denis .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (11) :1829-1835
[4]   Conversion to Complete Resection and/or Ablation Using Hepatic Artery Infusional Chemotherapy in Patients with Unresectable Liver Metastases from Colorectal Cancer: A Decade of Experience at a Single Institution [J].
Ammori, John B. ;
Kemeny, Nancy E. ;
Fong, Yuman ;
Cercek, Andrea ;
Dematteo, Ronald P. ;
Allen, Peter J. ;
Kingham, T. Peter ;
Gonen, Mithat ;
Paty, Philip B. ;
Jarnagin, William R. ;
D'Angelica, Michael I. .
ANNALS OF SURGICAL ONCOLOGY, 2013, 20 (09) :2901-2907
[5]   Quality of life following liver transplantation in patients with liver metastases from colorectal carcinoma [J].
Andersen, Marit Helen ;
Dueland, Svein ;
Hagness, Morten ;
Vidnes, Tone ;
Finstad, Ellen Drolsum ;
Wahl, Astrid Klopstad ;
Foss, Aksel .
SCANDINAVIAN JOURNAL OF CARING SCIENCES, 2012, 26 (04) :713-719
[6]   Liver transplantation: filling the gap between supply and demand [J].
Arulraj, Ramakrishnan ;
Neuberger, James .
CLINICAL MEDICINE, 2011, 11 (02) :194-198
[7]   Conversion strategies with chemotherapy plus targeted agents for colorectal cancer liver-only metastases: A systematic review [J].
Bolhuis, Karen ;
Kos, Milan ;
van Oijen, Martijn G. H. ;
Swijnenburg, Rutger-Jan ;
Punt, Cornelis J. A. .
EUROPEAN JOURNAL OF CANCER, 2020, 141 :225-238
[8]   Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines [J].
Bonney, Glenn K. ;
Chew, Claire Alexandra ;
Lodge, Peter ;
Hubbard, Joleen ;
Halazun, Karim J. ;
Trunecka, Pavel ;
Muiesan, Paolo ;
Mirza, Darius F. ;
Isaac, John ;
Laing, Richard W. ;
Iyer, Shridhar Ganpathi ;
Chee, Cheng Ean ;
Yong, Wei Peng ;
Muthiah, Mark Dhinesh ;
Panaro, Fabrizio ;
Sanabria, Juan ;
Grothey, Axel ;
Moodley, Keymanthri ;
Chau, Ian ;
Chan, Albert C. Y. ;
Wang, Chih Chi ;
Menon, Krishna ;
Sapisochin, Gonzalo ;
Hagness, Morten ;
Dueland, Svein ;
Line, Pal-Dag ;
Adam, Rene .
LANCET GASTROENTEROLOGY & HEPATOLOGY, 2021, 6 (11) :933-946
[9]   Liver Transplant for Nonresectable Colorectal Cancer Liver Metastases in South Africa: A Single-Center Case Series [J].
Botha, Jean ;
Demetriou, Georgia ;
Fabian, June ;
Etheredge, Harriet .
EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 2020, 18 (07) :842-846
[10]   Phase II Trial of Hepatic Artery Infusional and Systemic Chemotherapy for Patients With Unresectable Hepatic Metastases From Colorectal Cancer Conversion to Resection and Long-term Outcomes [J].
D'Angelica, Michael I. ;
Correa-Gallego, Camilo ;
Paty, Philip B. ;
Cercek, Andrea ;
Gewirtz, Alexandra N. ;
Chou, Joanne F. ;
Capanu, Marinella ;
Kingham, T. Peter ;
Fong, Yuman ;
DeMatteo, Ronald P. ;
Allen, Peter J. ;
Jarnagin, William R. ;
Kemeny, Nancy .
ANNALS OF SURGERY, 2015, 261 (02) :353-360