Cancer-associated fibroblasts in breast cancer in the single-cell era: Opportunities and challenges

被引：1

作者：

Yang, Jingtong ^{[1
]}

Xin, Benkai ^{[1
]}

Wang, Xiaoyu ^{[1
]}

Wan, Youzhong ^{[1
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2025年 / 1880卷 / 02期

关键词：

Breast cancer; Tumor microenvironment; cancer-associated fibroblasts; Single-cell sequencing; CARCINOMA-ASSOCIATED-FIBROBLASTS; MESENCHYMAL STEM-CELLS; ACTIVATION PROTEIN; TUMOR-GROWTH; STROMAL FIBROBLASTS; GENE-EXPRESSION; RNA-SEQ; HETEROGENEITY; BONE; DIFFERENTIATION;

D O I：

10.1016/j.bbcan.2025.189291

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is a leading cause of morbidity and mortality in women, and its progression is closely linked to the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs), key components of the TME, play a crucial role in promoting tumor growth by driving cancer cell proliferation, invasion, extracellular matrix (ECM) remodeling, inflammation, chemoresistance, and immunosuppression. CAFs exhibit considerable heterogeneity and are classified into subgroups based on different combinations of biomarkers. Single-cell RNA sequencing (scRNA-seq) enables high-throughput and high-resolution analysis of individual cells. Relying on this technology, it is possible to cluster complex CAFs according to different biomarkers to analyze the specific phenotypes and functions of different subpopulations. This review explores CAF clusters in breast cancer and their associated biomarkers, highlighting their roles in disease progression and potential for targeted therapies.

引用

页数：16

共 152 条

[1] Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions [J].

Alexander, Jennifer ;

Cukierman, Edna .

CURRENT OPINION IN CELL BIOLOGY, 2016, 42 :80-93

[2] Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises [J].

Armulik, Annika ;

Genove, Guillem ;

Betsholtz, Christer .

DEVELOPMENTAL CELL, 2011, 21 (02) :193-215

[3] Tumoral Immune Suppression by Macrophages Expressing Fibroblast Activation Protein-α and Heme Oxygenase-1 [J].

Arnold, James N. ;

Magiera, Lukasz ;

Kraman, Matthew ;

Fearon, Douglas T. .

CANCER IMMUNOLOGY RESEARCH, 2014, 2 (02) :121-126

[4] CAF-induced physical constraints controlling T cell state and localization in solid tumours [J].

Arpinati, Ludovica ;

Carradori, Giulia ;

Scherz-Shouval, Ruth .

NATURE REVIEWS CANCER, 2024, 24 (10) :676-693

[5]

Ayala G, 2003, CLIN CANCER RES, V9, P4792

[6] Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer [J].

Bagger, Mikkel Morsing ;

Sjoelund, Jonas ;

Kim, Jiyoung ;

Kohler, Katharina Theresa ;

Villadsen, Rene ;

Jafari, Abbas ;

Kassem, Moustapha ;

Pietras, Kristian ;

Ronnov-Jessen, Lone ;

Petersen, Ole William .

BREAST CANCER RESEARCH, 2024, 26 (01)

[7] Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche [J].

Baldominos, Pilar ;

Barbera-Mourelle, Alex ;

Barreiro, Olga ;

Huang, Yu ;

Wight, Andrew ;

Cho, Jae-Won ;

Zhao, Xi ;

Estivill, Guillem ;

Adam, Isam ;

Sanchez, Xavier ;

McCarthy, Shannon ;

Schaller, Julien ;

Khan, Zara ;

Ruzo, Albert ;

Pastorello, Ricardo ;

Richardson, Edward T. ;

Dillon, Deborah ;

Montero-Llopis, Paula ;

Barroso-Sousa, Romualdo ;

Forman, Juliet ;

Shukla, Sachet A. ;

Tolaney, Sara M. ;

Mittendorf, Elizabeth A. ;

von Andrian, Ulrich H. ;

Wucherpfennig, Kai W. ;

Hemberg, Martin ;

Agudo, Judith .

CELL, 2022, 185 (10) :1694-+

[8] Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing [J].

Bartoschek, Michael ;

Oskolkov, Nikolay ;

Bocci, Matteo ;

Lovrot, John ;

Larsson, Christer ;

Sommarin, Mikael ;

Madsen, Chris D. ;

Lindgren, David ;

Pekar, Gyula ;

Karlsson, Goran ;

Ringner, Markus ;

Bergh, Jonas ;

Bjorklund, Asa ;

Pietras, Kristian .

NATURE COMMUNICATIONS, 2018, 9

[9] IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma [J].

Biffi, Giulia ;

Oni, Tobiloba E. ;

Spielman, Benjamin ;

Hao, Yuan ;

Elyada, Ela ;

Park, Youngkyu ;

Preall, Jonathan ;

Tuveson, David A. .

CANCER DISCOVERY, 2019, 9 (02) :282-301

[10] Activated fibroblasts in cancer: Perspectives and challenges [J].

Caligiuri, Giuseppina ;

Tuveson, David A. .

CANCER CELL, 2023, 41 (03) :434-449

← 1 2 3 4 5 6 7 8 9 10 →