Harnessing Antitumor Immunity in Ovarian Cancer

被引：0
|
作者：
Kurnit, Katherine C. [1 ]
Odunsi, Kunle [1 ,2 ]
机构：
[1] Univ Chicago, Dept Obstet & Gynecol, Chicago, IL 60637 USA
[2] Univ Chicago Med, Comprehens Canc Ctr, Chicago, IL 60637 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2024年 / 14卷 / 12期
关键词：
REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; PHASE-I TRIAL; FAVORABLE PROGNOSIS; PLATINUM-RESISTANT; CISPLATIN RESISTANCE; THERAPEUTIC TARGET; INTERFERON-GAMMA; POOR-PROGNOSIS; OPEN-LABEL;
D O I：
10.1101/cshperspect.a041336
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Despite progress in other tumor types, immunotherapy is not yet part of the standard of care treatment for high-grade serous ovarian cancer patients. Although tumor infiltration by T cells is frequently observed in patients with ovarian cancer, clinical responses to immunotherapy remain low. Mechanisms for immune resistance in ovarian cancer have been explored and may provide insight into future approaches to improve response to immunotherapy agents. In this review, we discuss what is known about the immune landscape in ovarian cancer, review the available data for immunotherapy-based strategies in these patients, and provide possible future directions.
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页数：23
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