Recent progress on anti-cancer activity of thiadiazoles: A review

被引：0
作者：
Santhosh, C. R. [1 ,2 ]
Chinnam, Sampath [1 ,2 ]
Kottam, Nagaraju [1 ,2 ]
Amreen, S. [3 ]
Ananthnag, Guddekoppa S. [4 ]
Madhu, G. M. [2 ,5 ]
Gadde, Samata [6 ]
Fernandes, Viola Tressa [1 ,2 ]
Arnipalli, Haritha [1 ,2 ]
机构：
[1] MS Ramaiah Inst Technol, Dept Chem, Bengaluru 560054, Karnataka, India
[2] Visvesvaraya Technol Univ, Autonoumous Inst, Belgaum, India
[3] Jyoti Nivas Coll Autonomous, Dept Chem, Bengaluru 560095, Karnataka, India
[4] BMS Coll Engn, Dept Chem, Bull Temple Rd, Bengaluru 560019, Karnataka, India
[5] MS Ramaiah Inst Technol, Dept Chem Engn, Bengaluru 560054, Karnataka, India
[6] Acharya Nagarjuna Univ, Dept Biotechnol, Guntur 522510, Andhra Pradesh, India
来源：
RESULTS IN CHEMISTRY | 2025年 / 13卷
关键词：
Thiadiazoles; Anti-cancer; Heterocyclic compounds; Cancer cell lines; CELL-CYCLE ARREST; DERIVATIVES; DESIGN; THIAZOLE;
D O I：
10.1016/j.rechem.2024.101939
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cancer, a life-threatening condition which has become one of the deadliest disease impacting human health. Conventional drugs have significant side effects and are prone to drug resistance, whereas innovative therapies are costly and place a large load on patients. Despite the fact that several decades of medication research and discovery have produced a number of helpful chemotherapeutic drugs, the hunt for novel chemical entities with enhanced efficacy and safety is still ongoing. Thiadiazoles acts as inhibitors against several specific enzymes or signaling pathways. These compounds are frequently utilized when combined with other anti-cancer drugs to improve their efficacy. Thiadiazoles exhibit beneficial synergistic effects when used with other anticancer treatments like chemotherapy or targeted therapy. They have shown considerable anti-cancer action against various cancer cell lines. The review covers recent anti-cancer research findings from 2021 to 2024. This review aimed to give an overall description of thiadiazoles and analogs which demonstrated potential anti-cancer properties.
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页数：8
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