Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations

被引：4

作者：

Farina, Francesca R. ^{[1
,2
]}

Bridgeman, Katie ^{[3
]}

Gregory, Sarah ^{[3
,4
]}

Crivelli, Lucia ^{[6
]}

Foote, Isabelle F. ^{[7
,8
]}

Jutila, Otto-Emil, I ^{[5
]}

Kucikova, Ludmila ^{[9
]}

Mariano, Luciano, I ^{[2
,10
,11
]}

Nguyen, Kim-Huong ^{[2
,12
]}

Thayanandan, Tony ^{[13
]}

Akindejoye, Funmi ^{[2
,14
]}

Butler, Joe ^{[15
]}

Calandri, Ismael L. ^{[6
,16
]}

Chiesa, Scott ^{[17
]}

Dawson, Walter ^{[20
,21
]}

Deckers, Kay ^{[22
]}

de la Cruz Gongora, Vanessa ^{[2
,23
]}

Dounavi, Maria-Eleni ^{[24
]}

Govia, Ishtar ^{[18
,19
]}

Guzman-Velez, Edmarie ^{[25
,26
]}

Heikal, Shimaa A. ^{[27
]}

Hill-Jarrett, Tanisha G. ^{[28
,35
]}

Ibanez, Agustin ^{[2
,29
]}

James, Bryan ^{[30
]}

McGlinchey, Eimear ^{[2
]}

Mullin, Donncha S. ^{[5
]}

Muniz-Terrera, Graciela ^{[3
,31
]}

Caipa, Maritza Pintado ^{[35
]}

Qansuwa, Esraa M.

Robinson, Louise ^{[32
]}

Chadha, Antonella Santuccione ^{[33
]}

Shannon, Oliver M. ^{[32
]}

Su, Li ^{[9
,24
]}

Weidner, Wendy

Booi, Laura ^{[34
]}

机构：

[1] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

[2] Trinity Coll Dublin, Global Brain Hlth Inst GBHI, Dublin, Ireland

[3] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh Dementia Prevent, Edinburgh, Scotland

[4] Scottish Brain Sci, Edinburgh, Scotland

[5] Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh, Scotland

[6] Fleni, Montaneses, Buenos Aires, Argentina

[7] Univ Colorado Boulder, Inst Behav Genet, Boulder, CO USA

[8] Queen Mary Univ London, Wolfson Inst Populat Hlth, London, England

[9] Univ Sheffield, Sch Med & Populat Hlth, Sheffield, England

[10] Univ Fed Minas Gerais, Clin Hosp, Cognit & Behav Neurol Grp, Belo Horizonte, Brazil

[11] Univ Fed Minas Gerais, Inst Biol Sci, Neurosci Program, Belo Horizonte, Brazil

[12] Univ Queensland, Ctr Hlth Serv Res, Sch Publ Hlth, Brisbane, Qld, Australia

[13] Univ Oxford, Dept Psychiat, Oxford, England

[14] Univ Tasmania, Wicking Dementia Res & Educ Ctr, Hobart, Tas, Australia

[15] Univ Sunderland, Sch Psychol, Sunderland, England

[16] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam Neurosci, Amsterdam, Netherlands

[17] UCL, Inst Cognit Neurosci, London, England

[18] Univ West Indies, Caribbean Inst Hlth Res, Kingston, Jamaica

[19] UCL, Inst Global Hlth, London, England

[20] Oregon Hlth & Sci Univ, Sch Med, Portland, OR USA

[21] Portland State Univ, Inst Aging, Coll Urban & Publ Affairs, Portland, OR USA

[22] Maastricht Univ, Sch Mental Hlth & Neurosci, Maastricht, Netherlands

[23] Natl Inst Publ Hlth, Cuernavaca, Mexico

[24] Univ Cambridge, Dept Psychiat, Cambridge, England

[25] Massachusetts Gen Hosp, Boston, MA USA

[26] Harvard Med Sch, Dept Psychiat, Boston, MA USA

[27] Amer Univ Cairo, Inst Global Hlth & Human Ecol, Cairo, Egypt

[28] Memoryand Aging Ctr, San Francisco, CA USA

[29] Univ Adolfo Ibanez, Latin Amer Brain Hlth Inst BrainLat, Santiago, Chile

[30] Rush Univ, Med Ctr, Chicago, IL USA

[31] Ohio Univ, Heritage Coll Osteopath Med, Dept Social Med, Athens, OH USA

[32] Newcastle Univ, Populat Hlth Sci Inst, Newcastle Upon Tyne, England

[33] Womens Brain Fdn, Basel, Switzerland

[34] Leeds Beckett Univ, Ctr fo Dementia Res, Sch Hlth, Leeds, England

[35] Univ Calif San Francisco, GBHI, San Francisco, CA USA

来源：

LANCET HEALTHY LONGEVITY | 2024年 / 5卷 / 12期

基金：

英国经济与社会研究理事会; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

INTIMATE PARTNER VIOLENCE; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; UNITED-STATES; TOBACCO USE; PREVALENCE; INTERVENTION; INJURY; ASSOCIATION; EPIDEMIOLOGY;

D O I：

10.1016/j.lanhl.2024.100665

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Efforts to prevent dementia can benefit from precision interventions delivered to the right population at the right time; that is, when the potential to reduce risk is the highest. Young adults (aged 18-39 years) are a neglected population in dementia research and policy making despite being highly exposed to several known modifiable risk factors. The risk and protective factors that have the biggest effect on dementia outcomes in young adulthood, and how these associations differ across regions and groups, still remain unclear. To address these uncertainties, the Next Generation Brain Health team convened a multidisciplinary expert group representing 15 nations across six continents. We identified several high-priority modifiable factors in young adulthood and devised five key recommendations for promoting brain health, ranging from individual to policy levels. Increasing research and policy focus on brain health across the life course, inclusive of younger populations, is the next crucial step in the efforts to prevent dementia at the global level.

引用

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