Exploring Gut Microbiota Imbalance in Irritable Bowel Syndrome: Potential Therapeutic Effects of Probiotics and Their Metabolites

被引:0
作者
Mansilla, Maria Jose Garcia [1 ]
Sojo, Maria Jesus Rodriguez [1 ,2 ]
Lista, Andrea Roxana [2 ]
Mosqueda, Ciskey Vanessa Ayala [2 ]
Malagon, Antonio Jesus Ruiz [3 ]
Galvez, Julio [1 ,2 ,4 ]
Nogales, Alba Rodriguez [1 ,2 ]
Sanchez, Maria Jose Rodriguez [1 ,2 ]
机构
[1] Univ Granada, Ctr Invest Biomed CIBM, Dept Pharmacol, Granada 18071, Spain
[2] Inst Invest Biosanit Granada Ibs GRANADA, Granada 18012, Spain
[3] Inst Invest Biomed Malaga & Plataforma Nanomed IBI, Plataforma BIONAND, Malaga 29590, Spain
[4] Inst Salud Carlos III, CIBER Enfermedades Hepat & Digest CIBER EHD, Madrid 28029, Spain
关键词
Irritable bowel syndrome; gastrointestinal; treatment; probiotics; metabolites; symptoms; CHAIN FATTY-ACIDS; LACTOBACILLUS-HELVETICUS R0052; BIFIDOBACTERIUM-LONGUM R0175; FERMENTED MILK PRODUCT; BILE-ACID; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; DOUBLE-BLIND; BRAIN AXIS; VISCERAL HYPERSENSITIVITY;
D O I
10.3390/nu17010155
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Irritable bowel syndrome is a common functional gastrointestinal disorder characterized by recurrent abdominal discomfort, bloating, cramping, flatulence, and changes in bowel movements. The pathophysiology of IBS involves a complex interaction between motor, sensory, microbiological, immunological, and psychological factors. Diversity, stability, and metabolic activity of the gut microbiota are frequently altered in IBS, thus leading to a situation of gut dysbiosis. Therefore, the use of probiotics and probiotic-derived metabolites may be helpful in balancing the gut microbiota and alleviating irritable bowel syndrome symptoms. This review aimed to report and consolidate recent progress in understanding the role of gut dysbiosis in the pathophysiology of IBS, as well as the current studies that have focused on the use of probiotics and their metabolites, providing a foundation for their potential beneficial effects as a complementary and alternative therapeutic strategy for this condition due to the current absence of effective and safe treatments.
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页数:31
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