AcrIIIA1 is a protein-RNA anti-CRISPR complex that targets core Cas and accessory nucleases

被引：4

作者：

Chou-Zheng, Lucy ^{[1
]}

Howell, Olivia ^{[1
]}

Boyle, Tori A. ^{[1
]}

Hossain, Motaher ^{[1
]}

Walker, Forrest C. ^{[1
,2
]}

Sheriff, Emma K. ^{[2
]}

Aslan, Barbaros ^{[1
]}

Hatoum-Aslan, Asma ^{[1
]}

机构：

[1] Univ Illinois, Dept Microbiol, 601 S Goodwin Ave, Urbana, IL 61801 USA

[2] Univ Alabama, Dept Biol Sci, 1325 Hackberry Lane, Tuscaloosa, AL 35401 USA

来源：

NUCLEIC ACIDS RESEARCH | 2024年 / 52卷 / 22期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

EVOLUTIONARY CLASSIFICATION; STAPHYLOCOCCUS-AUREUS; DNA CLEAVAGE; DEGRADATION; RECOGNITION; MECHANISMS; MATURATION; IMMUNITY; LENGTH; ROLES;

D O I：

10.1093/nar/gkae1006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This manuscript describes a first-in-class anti-CRIPSR with a likely novel mechanism of action. The discovery of a type III-A antiCRISPR protein is exciting, and the method by which the authors discovered it is elegant a. Although there are some questions about the exact mechanism by which this Acr works, the mechanistic studies that were already in the paper provide considerable insight for future studies.

引用

页码：13490 / 13514

页数：25

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