Eugenia Pohliana Leaves Essential Oil Inhibits Fungal Virulence and Restores Antibiotic Efficacy in Multidrug-Resistant Bacterial Strains

被引：0

作者：

da Costa Silva, Jose Thyalisson ^{[1
]}

Menezes, Saulo Almeida ^{[2
]}

da Cruz, Rafael Pereira ^{[1
]}

Sombra Vandesmet, Lilian Cortez ^{[3
]}

dos Santos Correia, Maria Tereza ^{[4
]}

da Silva, Marcia Vanusa ^{[4
]}

Silva Pereira, Raimundo Luiz ^{[5
]}

Figueiredo dos Santos, Marcos Aurelio ^{[1
]}

Costa, Adrielle Rodrigues ^{[1
]}

da Silva, Viviane Bezerra ^{[1
]}

de Oliveira, Maraiza Gregorio ^{[1
]}

Goncalves Castro, Jose Walber ^{[5
]}

de Sousa Fernandes, Priscilla Augusta ^{[1
]}

da Silva Junior, Evandro G. ^{[5
]}

Melo Coutinho, Henrique Douglas ^{[5
]}

Goncalves Lima, Clara Mariana ^{[6
]}

Bezerra Morais-Braga, Maria Flaviana ^{[1
]}

Almeida-Bezerra, Jose Weverton ^{[5
]}

机构：

[1] Univ Reg Cariri, Dept Ciencias Biol, BR-63105000 Crato, CE, Brazil

[2] Univ Fed Rio Grande do Sul, Ctr Biotecnol, BR-91501970 Porto Alegre, RS, Brazil

[3] Ctr Univ Estacio Ceara, BR-63909003 Quixada, CE, Brazil

[4] Univ Fed Pernambuco, Dept Bioquim, BR-50670901 Recife, PE, Brazil

[5] Univ Reg Cariri, Dept Quim Biol, BR-63105000 Crato, CE, Brazil

[6] Univ Fed Lavras, Dept Food Sci, BR-37200900 Lavras, MG, Brazil

来源：

CHEMISTRY & BIODIVERSITY | 2024年 / 21卷 / 12期

关键词：

Essential oils; Terpenes; Antimicrobial activity; Antimicrobial resistance; Myrtaceae; CADINENE SESQUITERPENES; EUPATORIUM-ADENOPHORUM; CHEMICAL-COMPOSITION; L;

D O I：

10.1002/cbdv.202401604

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study aims to investigate the essential oil from leaves of Eugenia pohliana (EOEP) in regard to its chemical composition, antimicrobial and drug-enhancing activity, as well as the reduction of fungal virulence capacity. Chemical characterization using GC-MS showed as major components the sesquiterpenes delta-cadinene, Epi-alpha-Muurolol, and bicyclogermacrene. The results of antibacterial tests indicated that Staphylococcus aureus was more sensitive to EOEP, that also enhanced the efficacy of gentamicin, erythromycin, and norfloxacin. EOEP exhibited antifungal properties against Candida albicans, in addition to potentiating the effectiveness of fluconazole against Candida tropicalis. It showed anti-virulence effects in all fungal strains. These findings underscore E. pohliana as a potential candidate for the prospection of novel therapeutic agents to treat infectious diseases caused by resistant microbes.

引用

页数：8

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