Comparing the Clinical Trial Characteristics of Industry-Funded Trials and Non Industry-Funded Trials

被引：0

作者：

Hughes, Emily ^{[1
]}

Van Bakel, Tamara ^{[2
]}

Raudanskis, Ashley ^{[1
]}

Ray, Prachi ^{[1
]}

Hodzic-Santor, Benazir ^{[1
]}

Purohit, Ushma ^{[1
]}

Sacks, Chana A. ^{[3
,4
]}

Fralick, Michael ^{[1
,2
]}

机构：

[1] Sinai Hlth Syst, Div Gen Internal Med, Toronto, ON, Canada

[2] Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

[3] Harvard Med Sch, Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA USA

[4] Harvard Med Sch, Massachusetts Gen Hosp, Mongan Inst, Boston, MA USA

来源：

JOURNAL OF LAW MEDICINE & ETHICS | 2024年 / 52卷 / 03期

关键词：

Randomized Controlled Trials; Funder; Trial Characteristics; Pharmaceutical; Industry; Natural Language Processing;

D O I：

10.1017/jme.2024.135

中图分类号：

B82 [伦理学（道德学）];

学科分类号：

摘要：

We compared study characteristics of randomized controlled trials funded by industry (N=697) to those not funded by industry (N=835). RCTs published in high-impact journals are more likely to be blinded, more likely to include a placebo, and more likely to post trial results on ClinicalTrials.gov. Our findings emphasize the importance of evaluating the quality of an RCT based on its methodological rigor, not its funder type.

引用

页码：693 / 700

页数：8

共 28 条

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[16] Recent trends and controversies in industry-sponsored clinical trials
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[17] Industry sponsorship and authorship of clinical trials over 20 years
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[18] Industry sponsorship bias in clinical trials in implant dentistry: Systematic review and meta-regression
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[19] Methodological Characteristics of Clinical Trials: Impact of Mandatory Trial Registration
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[20] Implementation of an authorship algorithm for industry-sponsored clinical trials at Celgene: a case study
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