Comparing the Clinical Trial Characteristics of Industry-Funded Trials and Non Industry-Funded Trials

被引：0

作者：

Hughes, Emily ^{[1
]}

Van Bakel, Tamara ^{[2
]}

Raudanskis, Ashley ^{[1
]}

Ray, Prachi ^{[1
]}

Hodzic-Santor, Benazir ^{[1
]}

Purohit, Ushma ^{[1
]}

Sacks, Chana A. ^{[3
,4
]}

Fralick, Michael ^{[1
,2
]}

机构：

[1] Sinai Hlth Syst, Div Gen Internal Med, Toronto, ON, Canada

[2] Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

[3] Harvard Med Sch, Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA USA

[4] Harvard Med Sch, Massachusetts Gen Hosp, Mongan Inst, Boston, MA USA

来源：

JOURNAL OF LAW MEDICINE & ETHICS | 2024年 / 52卷 / 03期

关键词：

Randomized Controlled Trials; Funder; Trial Characteristics; Pharmaceutical; Industry; Natural Language Processing;

D O I：

10.1017/jme.2024.135

中图分类号：

B82 [伦理学（道德学）];

学科分类号：

摘要：

We compared study characteristics of randomized controlled trials funded by industry (N=697) to those not funded by industry (N=835). RCTs published in high-impact journals are more likely to be blinded, more likely to include a placebo, and more likely to post trial results on ClinicalTrials.gov. Our findings emphasize the importance of evaluating the quality of an RCT based on its methodological rigor, not its funder type.

引用

页码：693 / 700

页数：8

共 28 条

[1] Credibility of industry-funded clinical trials
Tohen, Mauricio
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2013, 16 (08) : 1879 - 1884
[2] Developing a clinical trial governance framework for pharmaceutical industry-funded clinical trials
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AlGhafli, Shamsa
AlJaberi, Ayesha
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[3] Industry-funded versus non-profit-funded critical care research: a meta-epidemiological overview
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[4] High-impact trials with genetic and -omics information focus on cancer mutations, are industry-funded, and less transparent
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Pastorino, Roberta
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[5] The interface between publicly funded and industry-funded research in pediatric psychopharmacology: Opportunities for integration and collaboration
Vitiello, B
Heiligenstein, JH
Riddle, MA
Greenhill, LL
Fegert, JM
BIOLOGICAL PSYCHIATRY, 2004, 56 (01) : 3 - 9
[6] Industry funded clinical trials: bias and quality
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CURRENT MEDICAL RESEARCH AND OPINION, 2012, 28 (01) : 23 - 25
[7] Industry-funded versus non-profit-funded critical care research: a meta-epidemiological overview
Janiaud, Perrine
Cristea, Ioana-Alinea
Ioannidis, John P. A.
INTENSIVE CARE MEDICINE, 2018, 44 (10) : 1613 - 1627
[8] Is gambling industry-funded research necessarily a conflict of interest? A reply to Cassidy (2014)
Wohl, Michael J. A.
Wood, Richard T. A.
INTERNATIONAL GAMBLING STUDIES, 2015, 15 (01) : 12 - 14
[9] A critique of Fox's industry-funded report into the drivers of anti-social behaviour in the night-time economies of Australia and New Zealand
Jackson, Nicki
Kypri, Kypros
ADDICTION, 2016, 111 (03) : 552 - 557
[10] Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials
Lees, Jennifer S.
Hanlon, Peter
Butterly, Elaine W.
Wild, Sarah H.
Mair, Frances S.
Taylor, Rod S.
Guthrie, Bruce
Gillies, Katie
Dias, Sofia
Welton, Nicky J.
McAllister, David A.
BMJ MEDICINE, 2022, 1 (01):

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