Six-Week Supplementation with Creatine in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Magnetic Resonance Spectroscopy Feasibility Study at 3 Tesla

被引:1
作者
Godlewska, Beata R. [1 ,2 ]
Sylvester, Amy L. [1 ,3 ]
Emir, Uzay E. [4 ,5 ]
Sharpley, Ann L. [1 ]
Clarke, William T. [4 ]
Martens, Marieke A. G. [1 ,2 ,4 ]
Cowen, Philip J. [1 ,2 ]
机构
[1] Univ Oxford, Dept Psychiat, Oxford OX3 7JX, England
[2] Oxford Hlth NHS Fdn Trust, Oxford OX4 4XN, England
[3] Maastricht Univ, Mental Hlth & Neurosci Res Inst, Dept Psychiat & Neuropsychol, NL-6229 ER Maastricht, Netherlands
[4] Univ Oxford, Wellcome Ctr Integrat Neuroimaging, Oxford OX1 2JD, England
[5] Univ N Carolina, Sch Med, Dept Radiol, Chapel Hill, NC 27599 USA
基金
英国医学研究理事会; 英国惠康基金;
关键词
myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); creatine monohydrate; supplementation; MRS; cognition; hand grip strength; ANTERIOR CINGULATE CORTEX; HUMAN BRAIN; DOUBLE-BLIND; SHORT-ECHO;
D O I
10.3390/nu16193308
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic medical condition with no specific pharmacological treatment. Creatine, a nutrient essential for maintaining energy homeostasis in the cells, is a candidate for interventions in ME/CFS. Methods: Fourteen participants with ME/CFS received supplementation with 16 g creatine monohydrate for 6 weeks. Before starting creatine and on the last day of treatment, participants underwent brain magnetic resonance spectroscopy (MRS) scanning of the pregenual anterior cingulate cortex (pgACC) and dorsolateral prefrontal cortex (DLPFC), followed by symptom, cognition, and hand-grip strength assessments. Results: Eleven participants completed the study. Creatine treatment increased creatine concentration in both the pgACC and DLPFC (p = 0.004 and 0.012, respectively), decreased fatigue and reaction time (RT) on congruent and incongruent trials of the Stroop test (p = 0.036 and 0.014, respectively), and increased hand-grip strength (p = 0.0004). There was a positive correlation between increases in pgACC creatine and changes in RT on Stroop congruent and incongruent trials (p = 0.048 and p = 0.022, respectively). Creatine was well tolerated, and none of the participants stopped treatment. Conclusion: Creatine supplementation over six weeks in ME/CFS patients increased brain creatine and improved fatigue and some aspects of cognition. Despite its methodological limitations, this study encourages placebo-controlled investigations of creatine treatment in ME/CFS.
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页数:13
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