Transcription factor addictions: exploring the potential Achilles' Heel of endometriosis

被引:0
作者
Yang, Yang [1 ]
Du, Yi [1 ]
Ma, Xuelei [2 ]
Yuan, Gang [3 ]
Li, Guobo [4 ]
Zhang, Qian [1 ]
Zhou, Shengtao [1 ]
机构
[1] Sichuan Univ & Collaborat Innovat Ctr, West China Second Univ Hosp, State Key Lab Biotherapy, Dept Obstet & Gynecol,Key Lab Birth Defects & Rela, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy,State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[3] Sichuan Univ, Inst Thorac Oncol, West China Hosp, Dept Thorac Surg, Chengdu 610041, Peoples R China
[4] Sichuan Univ, West China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China
来源
SCIENCE CHINA-LIFE SCIENCES | 2025年
基金
中国国家自然科学基金;
关键词
endometriosis; transcription factors; drug target; ESTROGEN-RECEPTOR-BETA; KAPPA-B ACTIVATION; STROMAL CELLS; MESENCHYMAL TRANSITIONS; PROSTAGLANDIN E-2; ER-BETA; EXPRESSION; GROWTH; GENE; PROLIFERATION;
D O I
10.1007/s11427-024-2832-8
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A considerable number of women of reproductive age suffer from endometriosis worldwide. There is a significant physical, mental, and financial burden on patients affected by this condition in terms of pelvic pain, either continuously or intermittently, dysmenorrhea, infertility, and a higher risk of certain types of cancer. Several treatments available in clinical settings for endometriosis management do not provide adequate efficacy and have undesirable side effects. Transcription factors (TFs) are crucial regulators of key biological processes involved in endometriosis. Here, we elaborated on the research progress regarding the crucial roles of TFs in endometriosis, emphasizing their implications for clinical outcomes and critical therapeutic contributions. By delving into their involvement in key processes, such as cell proliferation and apoptosis, we revealed the multifaceted role of key TFs in disease progression. We aimed to provide a systemic understanding of TFs regulation in endometriosis pathogenesis, establishing a foundation for innovative treatment approaches.
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页数:13
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