Anti-Eczema Activity of Bacterial Red Pigment Prodigiosin: an in silico study

Eczema is a chronic inflammatory disease of the skin with itching, rashes, dryness, blisters, and scaly patches. As of now, there is no proper treatment for eczema. The drugs available so far do not respond after using for some time and result in undesirable side effects viz. permanent skin withdrawing and systemic stopping of adrenal function. To find a solution for eczema, anti-eczema activity of prodigiosin, a red bacterial pigment which was reported to show many promising potential therapeutic activities viz. antimicrobial, anti-protozoan, insecticidal, anti-parasitic, immune modulator, anticancer and antiviral activities was studies in silico, targeting different proteins involved in causing the disease. From the results, it is clear that strong binding affinity of prodigiosin with the proteins involved in causing eczema was recorded. Hence, it can be concluded that prodigiosin, the red pigment of bacterial origin can be developed as a promising anti-eczema drug. However, further investigations are needed.