Antiphospholipid Antibodies as Key Players in Systemic Lupus Erythematosus: The Relationship with Cytokines and Immune Dysregulation

被引：2

作者：

Richter, Patricia ^{[1
]}

Badescu, Minerva Codruta ^{[2
,3
]}

Rezus, Ciprian ^{[2
,3
]}

Ouatu, Anca ^{[2
,3
]}

Dima, Nicoleta ^{[2
,3
]}

Popescu, Diana ^{[2
]}

Burlui, Alexandra Maria ^{[1
,4
]}

Bratoiu, Ioana ^{[1
,4
]}

Mihai, Ioana Ruxandra ^{[1
,4
]}

Rezus, Elena ^{[1
,4
]}

机构：

[1] Grigore T Popa Univ Med & Pharm, Dept Rheumatol & Physiotherapy, 16 Univ St, Iasi 700115, Romania

[2] Grigore T Popa Univ Med & Pharm, Dept Internal Med, 16 Univ St, Iasi 700115, Romania

[3] St Spiridon Cty Emergency Clin Hosp, IIIrd Internal Med Clin, 1 Independence Blvd, Iasi 700111, Romania

[4] Clin Rehabil Hosp, Rheumatol Clin 1, 14 Pantelimon Halipa St, Iasi 700661, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 20期

关键词：

systemic lupus erythematosus; antiphospholipid syndrome; antiphospholipid antibodies; inflammation; immunity; thrombosis; BETA(2)-GLYCOPROTEIN I; CLASSIFICATION CRITERIA; ENDOTHELIAL ACTIVATION; REVISED CRITERIA; DISEASE-ACTIVITY; TISSUE FACTOR; THROMBOSIS; ANTICOAGULANT; PATHOGENESIS; INTERFERON;

D O I：

10.3390/ijms252011281

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by an overproduction of cytokines, such as interleukins and interferons, contributing to systemic inflammation and tissue damage. Antiphospholipid syndrome is a thrombo-inflammatory autoimmune disease affecting a third of SLE patients. We performed an in-depth analysis of the available literature, and we highlighted the complex interplay between immunity, inflammation, and thrombosis, the three major pathogenic pathways that are trapped in a mutually reinforcing destructive loop.

引用

页数：23

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