Electromagnetic pulse exposure induces neuroinflammation and blood-brain barrier disruption by activating the NLRP3 inflammasome/ NF-κB signaling pathway in mice

被引：0

作者：

Lin, Yanyun ^{[1
,2
]}

Lang, Haiyang ^{[1
,3
]}

Gao, Peng ^{[1
]}

Miao, Xia ^{[1
]}

Guo, Qiyan ^{[1
]}

Hao, Yue ^{[1
]}

Ai, Tao ^{[1
]}

Li, Jing ^{[1
]}

Zhang, Jie ^{[1
]}

Guo, Guozhen ^{[1
]}

机构：

[1] Airforce Med Univ, Fac Prevent Med, Dept Radiat Med & Protect, Xian 710032, Peoples R China

[2] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Key Lab Biomed Informat Engn, Minist Educ, Xian 710049, Peoples R China

[3] Airforce Med Univ, Key Lab Hazard Assessment & Control Special Operat, Minist Educ, Xian 710032, Peoples R China

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2025年 / 292卷

关键词：

Electromagnetic pulses (EMP); Microglia cells; Oxidative stress; Neuroinflammation; NLRP3 inflammasome/NF-kappa B; Blood-brain barrier (BBB); CENTRAL NERVOUS SYSTEM; MICROGLIA; RADIATION; MACROPHAGES; PHYSIOLOGY; DISEASE; IMPACT;

D O I：

10.1016/j.ecoenv.2025.117972

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The electromagnetic pulse (EMP) is a widespread electromagnetic disturbance that can disrupt electronic systems and pose health risks to personnel in operational areas. The biological effects of EMP radiation, especially on the central nervous system (CNS), are not yet fully understood but are gaining attention. This study examines the impact of EMP on the CNS using microglial cells as a model system. We found that mice exposed to a field strength of 600 kV/m with 1000 pulses per day for two weeks exhibited increased levels of oxidative stress. This exposure induced a microglia polarization to the M1 state, leading to neuroinflammation and disruption of the blood-brain barrier (BBB) by the pro-inflammatory response of microglia. Further analysis revealed that the NLRP3 inflammasome/NF-kappa B signaling pathway modulates the pro-inflammatory mechanisms of EMP irradiation. In conclusion, our findings show that EMP irradiation triggers neuroinflammation and BBB damage via NLRP3 inflammasome/NF-kappa B activation. This research highlights the effects of EMP radiation on the CNS and offers valuable insights into the potential targets for biomedical protection against it.

引用

页数：12

共 55 条

[21] Lampert P.W., Davis R.L., DELAYED EFFECTS OF RADIATION ON THE HUMAN CENTRAL NERVOUS SYSTEM
[22] “EARLY” AND “LATE” DELAYED REACTIONS, Neurology, 14, pp. 912-917, (1964)
[23] Lan Y., Zhang X., Liu S., Guo C., Jin Y., Li H., Wang L., Zhao J., Hao Y., Li Z., Liu Z., Ginhoux F., Xie Q., Xu H., Jia J.M., He D., Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury, Immunity, 57, pp. 349-363, (2024)
[24] Langen U.H., Ayloo S., Gu C., Development and Cell Biology of the Blood-Brain Barrier, Annu Rev. Cell Dev. Biol., 35, pp. 591-613, (2019)
[25] Li J.J., Deng B., Zhang X.J., Lv M.M., Zhao H., Wang J., Liu J.D., Han R.L., Sun X.D., Isoflurane Preconditioning Attenuates Brain Injury Induced by Electromagnetic Pulse via the TLR4/NFκB Signaling Pathway, Oxid. Med. Cell. Longev., 2019, (2019)
[26] Li Q., Barres B.A., Microglia and macrophages in brain homeostasis and disease, Nat. Rev. Immunol., 18, pp. 225-242, (2018)
[27] Liu Y.G., Chen J.K., Zhang Z.T., Ma X.J., Chen Y.C., Du X.M., Liu H., Zong Y., Lu G.C., NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages, Cell Death Dis., 8, (2017)
[28] Martino A., Krainik A., Pasteris C., Hoffmann D., Chabardes S., Berger F., Le Bas J.F., Cantin S., Attye A., Grand S., Neurological imaging of brain damages after radiotherapy and/or chimiotherapy, J. Neuroradiol., 41, pp. 52-70, (2014)
[29] Masuda T., Sankowski R., Staszewski O., Bottcher C., Amann L., Sagar, Scheiwe C., Nessler S., Kunz P., van Loo G., Coenen V.A., Reinacher P.C., Michel A., Sure U., Gold R., Grun D., Priller J., Stadelmann C., Prinz M., Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution, Nature, 566, pp. 388-392, (2019)
[30] Mayer M.G., Fischer T., Microglia at the blood brain barrier in health and disease, Front. Cell. Neurosci., 18, (2024)

← 1 2 3 4 5 6 →