Epigenetics in autoimmune diseases: Unraveling the hidden regulators of immune dysregulation

被引：1
|
作者：
Bagni, Giacomo [1 ,2 ]
Biancalana, Edoardo [1 ,3 ]
Chiara, Emanuele [1 ,3 ]
Costanzo, Iole [1 ,3 ]
Malandrino, Danilo [1 ,3 ]
Lastraioli, Elena [1 ]
Palmerini, Miki [1 ]
Silvestri, Elena [1 ,3 ]
Urban, Maria Letizia [1 ,3 ]
Emmi, Giacomo [4 ,5 ,6 ]
机构：
[1] Univ Florence, Dept Expt & Clin Med, Florence, Italy
[2] Univ Turin, Dept Clin & Biol Sci, Turin, Italy
[3] Careggi Univ Hosp, Interdisciplinary Internal Med Unit, Florence, Italy
[4] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy
[5] Cattinara Univ Hosp, Clin Med & Rheumatol Unit, Trieste, Italy
[6] Monash Univ, Dept Med, Ctr Inflammatory Dis, Monash Med Ctr, Melbourne, Australia
来源：
AUTOIMMUNITY REVIEWS | 2025年 / 24卷 / 06期
关键词：
Epigenetics; Autoimmunity; Autoimmune diseases; microRNA; DNA methylation; Histone modifications; Beh & ccedil; et's syndrome; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CD4(+) T-CELLS; DNA METHYLATION; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; GENE-EXPRESSION; BEHCETS-DISEASE; CELIAC-DISEASE; PROMOTER METHYLATION; HISTONE MODIFICATION;
D O I：
10.1016/j.autrev.2025.103784
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Autoimmune diseases result from complex interactions between genetic and environmental factors. Recent advances in epigenetic research shed light on the intricate regulatory mechanisms that contribute to the development and progression of such conditions. The present review aims to explore the role of epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, in the context of autoimmune diseases. We discuss the current understanding of epigenetic alterations associated with various autoimmune disorders, their impact on immune cell function, and their potential as innovative therapeutic targets. Additionally, we highlight the main future directions in the field of epigenetics in autoimmunity.
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收藏
页数：17
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