α-Glucosidase inhibitory and tyrosinase inhibitory activities of alkaloids from Stephania kwangsiensis

被引：0

作者：

Zeng, Siwen ^{[1
,2
]}

Li, Jing ^{[2
,3
]}

Huang, Yonglin ^{[2
]}

Wang, Yafeng ^{[2
]}

Yang, Bingyuan ^{[2
]}

Liu, Zhangbin ^{[2
]}

Li, Guiqin ^{[2
]}

Ge, Li ^{[3
]}

He, Ruijie ^{[2
]}

Yang, Kedi ^{[1
,3
]}

机构：

[1] Guangxi Univ, Sch Chem & Chem Engn, Nanning, Peoples R China

[2] Guangxi Inst Bot, Guangxi Key Lab Plant Funct Phytochem & Sustainabl, Guilin, Peoples R China

[3] Guangxi Univ, Med Coll, Nanning, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2025年

基金：

中国国家自然科学基金;

关键词：

<italic>Stephania kwangsiensis</italic>; menispermaceae; alkaloids; tyrosinase inhibitory activity; alpha-glucosidase inhibitory activity; APORPHINE ALKALOIDS; CONSTITUENTS; ROOTS;

D O I：

10.1080/14786419.2025.2479248

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

From the tubers of Stephania kwangsiensis, two undescribed alkaloids (7 R, 14S)-thaicanine alpha-N-oxide (1) and (6S, 6aS, 7 R)-sukhodianine alpha-N-oxide (2) were isolated, adding 14 alkaloids which had been reported earlier. The structural definition of 1-16 was achieved by analysing mass spectrum and nuclear magnetic resonance data, as well as comparing the calculated ECD spectra with experimental ones. N-O-Dimethylthaicanine (12) and polycarpine (14) displayed favourable alpha-glucosidase inhibitory activities in vitro with the IC50 values of 3.001 +/- 0.019 mmol/L, 2.132 +/- 0.009 mmol/L, respectively. Dactycapnine B (8) demonstrated tyrosinase inhibitory activity with an IC50 value of 2.353 +/- 0.136 mmol/L.

引用

页数：9

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