Self-criticism predicts antidepressant effects of intermittent theta-burst stimulation in Major Depressive Disorder

被引:0
作者
Jomha, Aliya [1 ,2 ,3 ,4 ]
Sohn, Myren N. [2 ,3 ,4 ]
Watson, Molly [2 ,3 ,4 ]
Kopala-Sibley, Daniel C. [2 ,3 ,4 ]
Mcgirr, Alexander [2 ,3 ,4 ]
机构
[1] Mt Royal Univ, Dept Psychol, Calgary, AB, Canada
[2] Univ Calgary, Dept Psychiat, 3280 Hosp Drive NW,TRW-4D68, Calgary, AB T2N 4Z6, Canada
[3] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada
[4] Mathison Ctr Mental Hlth Res & Educ, Calgary, AB, Canada
关键词
Self-criticism; Depressive experiences questionnaire; Major Depressive Disorder; MDD; D-Cycloserine; NMDA receptor; Transcranial magnetic stimulation; Intermittent theta burst stimulation; iTBS; TREATMENT-RESISTANT DEPRESSION; D-CYCLOSERINE AUGMENTATION; STRESSFUL LIFE EVENTS; MOTOR PLASTICITY; RATING-SCALE; DEPENDENCY; PERFECTIONISM; PERSONALITY; THERAPY; RTMS;
D O I
10.1016/j.jad.2024.12.006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Self-criticism is a risk factor for depression and depressive symptom persistence, however higher degrees of self-criticism have been associated with greater antidepressant benefits from repetitive transcranial magnetic stimulation (rTMS), suggesting that self-criticism may act as a proxy for function of the targeted circuit. We test this hypothesis using secondary data from an rTMS treatment trial where an NMDA receptor agonist (DCycloserine) was used to enhance TMS synaptic plasticity to improve efficacy. We hypothesized that selfcriticism would be more strongly associated with treatment outcome when stimulation was paired with DCycloserine than with a placebo. Methods: In a 4-week single-site double-blind randomized placebo-controlled trial, fifty adults with Major Depressive Disorder (MDD) (NCT03937596) were randomized to receive placebo or D-Cycloserine (100 mg) with daily intermittent theta-burst stimulation (iTBS) to the left dorsolateral prefrontal cortex (DLPFC). At baseline and after treatment, self-criticism was assessed using the Depressive Experiences Questionnaire as a secondary trial outcome and depressive symptoms were assessed using the clinician rated Montgomery Asberg Depression Rating scale (MADRS). Clinical response was defined as a >= 50 % decrease on the MADRS. Results: Self-criticism differentially predicted antidepressant effects when operationalized as both percent decrease on the MADRS and clinical response (>= 50 % decrease), with a statistically significantly stronger association in the iTBS+D-Cycloserine group than the iTBS+Placebo condition. Self-criticism did not significantly change in either condition over the course of treatment. Conclusions: Our data suggests that iTBS to the left DLPFC engages a circuit related to self-criticism. Higher levels of self-criticism predicted better response to iTBS with an adjuvant that enhances synaptic plasticity. This suggests that personality traits may be used to tailor non-invasive neurostimulation treatments.
引用
收藏
页码:210 / 215
页数:6
相关论文
共 50 条
[41]   Bilateral theta-burst stimulation on emotional processing in major depressive disorder: A functional neuroimaging study from a randomized, double-blind, sham-controlled trial [J].
Chou, Po-Han ;
Tu, Cheng-Hao ;
Chen, Chun-Ming ;
Lu, Ming-Kuei ;
Tsai, Chon-Haw ;
Hsieh, Wan-Ting ;
Lai, Hui-Chen ;
Satyanarayanan, Senthil Kumaran ;
Su, Kuan-Pin .
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2023, 77 (04) :233-240
[42]   An Accelerated Course of TMS Using Intermittent Theta Burst for Veterans With Major Depressive Disorder [J].
Zuschlag, Zachary ;
Bajor, Laura ;
Van Trees, Kimberly ;
Phillips, Sean ;
Sullivan, Greg ;
Burke, Christine ;
Kozel, F. Andrew .
BIOLOGICAL PSYCHIATRY, 2022, 91 (09) :S237-S237
[43]   The influence of menstrual phase on synaptic plasticity induced via intermittent theta-burst stimulation [J].
Ramdeo, K. R. ;
Adams, F. C. ;
Drapeau, C. C. ;
Foglia, S. D. ;
Cuizon, M. C. ;
Sader, M. A. ;
Nucci, R. ;
Nelson, A. J. .
NEUROSCIENCE, 2024, 558 :122-127
[44]   Case report: Tremor in the placebo condition of a blinded clinical trial of intermittent theta-burst stimulation for cocaine use disorder [J].
Steele, Vaughn R. ;
Rotenberg, Alexander ;
Philip, Noah S. ;
Hallett, Mark ;
Stein, Elliot A. ;
Salmeron, Betty Jo .
FRONTIERS IN PSYCHIATRY, 2024, 15
[45]   Heart Rate Variability Features as Predictors of Intermittent Theta-Burst Stimulation Response in Posttraumatic Stress Disorder [J].
Cosmo, Camila ;
Seligowski, Antonia, V ;
Aiken, Emily M. ;
van't Wout-Frank, Mascha ;
Philip, Noah S. .
NEUROMODULATION, 2022, 25 (04) :588-595
[46]   Effects of intermittent theta-burst transcranial magnetic stimulation on cognition and hippocampal volumes in bipolar depression [J].
Torres, Ivan J. J. ;
Ge, Ruiyang ;
McGirr, Alexander ;
Vila-Rodriguez, Fidel ;
Ahn, Sharon ;
Basivireddy, Jayasree ;
Walji, Nazlin ;
Frangou, Sophia ;
Lam, Raymond W. W. ;
Yatham, Lakshmi N. N. .
DIALOGUES IN CLINICAL NEUROSCIENCE, 2023, 25 (01) :24-32
[47]   Subcortical Intermittent Theta-Burst Stimulation (iTBS) Increases Theta-Power in Dorsolateral Prefrontal Cortex (DLPFC) [J].
Bentley, J. Nicole ;
Irwin, Zachary T. ;
Black, Sarah D. ;
Roach, Megan L. ;
Vaden, Ryan J. ;
Gonzalez, Christopher L. ;
Khan, Anas U. ;
El-Sayed, Galal A. ;
Knight, Robert T. ;
Guthrie, Barton L. ;
Walker, Harrison C. .
FRONTIERS IN NEUROSCIENCE, 2020, 14
[48]   Effects of intermittent theta burst stimulation on spasticity in patients with multiple sclerosis [J].
Mori, F. ;
Codeca, C. ;
Kusayanagi, H. ;
Monteleone, F. ;
Boffa, L. ;
Rimano, A. ;
Bernardi, G. ;
Koch, G. ;
Centonze, D. .
EUROPEAN JOURNAL OF NEUROLOGY, 2010, 17 (02) :295-300
[49]   Aftereffects of Intermittent Theta-Burst Stimulation in Adjacent, Non-Target Muscles [J].
Morris, Timothy P. ;
Davila-Perez, Paula ;
Jannati, Ali ;
Menardi, Arianna ;
Pascual-Leone, Alvaro ;
Fried, Peter J. .
NEUROSCIENCE, 2019, 418 :157-165
[50]   Intermittent theta-burst transcranial magnetic stimulation for autism spectrum disorder: an open-label pilot study [J].
Abujadi, Caio ;
Croarkin, Paul E. ;
Bellini, Bianca B. ;
Brentani, Helena ;
Marcolin, Marco A. .
REVISTA BRASILEIRA DE PSIQUIATRIA, 2018, 40 (03) :309-311