Reprogrammed lipid metabolism in advanced resistant cancers: an upcoming therapeutic opportunity

被引：1

作者：

Cioce, Mario ^{[1
,2
]}

Arbitrio, Mariamena ^{[3
]}

Polera, Nicoletta ^{[3
]}

Altomare, Emanuela ^{[4
]}

Rizzuto, Antonia ^{[5
]}

De Marco, Carmela ^{[6
]}

Fazio, Vito Michele ^{[1
,2
]}

Viglietto, Giuseppe ^{[6
]}

Lucibello, Maria ^{[3
,6
]}

机构：

[1] Univ Campus Biomed Rome, Dept Med, Lab Mol Med & Biotechnol, Rome, Italy

[2] Natl Res Council Italy CNR, Inst Translat Pharmacol, I-00133 Rome, Italy

[3] Natl Res Council Italy CNR, Inst Biomed Res & Innovat, Dept Biomed Sci, Viale Tommaso Campanella 115, I-88100 Catanzaro, Italy

[4] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy

[5] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, I-88100 Catanzaro, Italy

[6] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, I-88100 Catanzaro, Italy

来源：

CANCER DRUG RESISTANCE | 2024年 / 7卷

关键词：

Metabolic signaling; therapy resistance; tumor microenvironment; metastasis; immune evasion; FATTY-ACID-METABOLISM; TUMOR MICROENVIRONMENT; CELLS; OBESITY; CHEMOTHERAPY; RADIOTHERAPY; METASTASIS; INHIBITION; SURVIVAL; IMPAIRS;

D O I：

10.20517/cdr.2024.131

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resistance of cancer to therapy is the main challenge to its therapeutic management and is still an unsolved problem. Rearranged lipid metabolism is a strategy adopted by cancer cells to counteract adversity during their evolution toward aggressiveness and immune evasion. This relies on several mechanisms, ranging from altered metabolic pathways within cancer cells to evolved dynamic crosstalk between cancer cells and the tumor microenvironment (TME), with some cell populations at the forefront of metabolic reprogramming, thereby contributing to the resistance of the whole ecosystem during therapy. Unraveling these mechanisms may contribute to the development of more effective combinatorial therapy in resistant patients. This review highlights the alterations in lipid metabolism that contribute to cancer progression, with a focus on the potential clinical relevance of such for the of resistance.

引用

页数：23

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