Reprogrammed lipid metabolism in advanced resistant cancers: an upcoming therapeutic opportunity

被引：1
作者：
Cioce, Mario [1 ,2 ]
Arbitrio, Mariamena [3 ]
Polera, Nicoletta [3 ]
Altomare, Emanuela [4 ]
Rizzuto, Antonia [5 ]
De Marco, Carmela [6 ]
Fazio, Vito Michele [1 ,2 ]
Viglietto, Giuseppe [6 ]
Lucibello, Maria [3 ,6 ]
机构：
[1] Univ Campus Biomed Rome, Dept Med, Lab Mol Med & Biotechnol, Rome, Italy
[2] Natl Res Council Italy CNR, Inst Translat Pharmacol, I-00133 Rome, Italy
[3] Natl Res Council Italy CNR, Inst Biomed Res & Innovat, Dept Biomed Sci, Viale Tommaso Campanella 115, I-88100 Catanzaro, Italy
[4] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy
[5] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, I-88100 Catanzaro, Italy
[6] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, I-88100 Catanzaro, Italy
来源：
CANCER DRUG RESISTANCE | 2024年 / 7卷
关键词：
Metabolic signaling; therapy resistance; tumor microenvironment; metastasis; immune evasion; FATTY-ACID-METABOLISM; TUMOR MICROENVIRONMENT; CELLS; OBESITY; CHEMOTHERAPY; RADIOTHERAPY; METASTASIS; INHIBITION; SURVIVAL; IMPAIRS;
D O I：
10.20517/cdr.2024.131
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Resistance of cancer to therapy is the main challenge to its therapeutic management and is still an unsolved problem. Rearranged lipid metabolism is a strategy adopted by cancer cells to counteract adversity during their evolution toward aggressiveness and immune evasion. This relies on several mechanisms, ranging from altered metabolic pathways within cancer cells to evolved dynamic crosstalk between cancer cells and the tumor microenvironment (TME), with some cell populations at the forefront of metabolic reprogramming, thereby contributing to the resistance of the whole ecosystem during therapy. Unraveling these mechanisms may contribute to the development of more effective combinatorial therapy in resistant patients. This review highlights the alterations in lipid metabolism that contribute to cancer progression, with a focus on the potential clinical relevance of such for the of resistance.
引用
收藏
页数：23
相关论文
共 90 条
  • [1] Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer
    Abdulla, Naaziyah
    Vincent, C. Theresa
    Kaur, Mandeep
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [2] Fatty acid synthase regulates the chemosensitivity of breast cancer cells to cisplatin-induced apoptosis
    Al-Bahlani, Shadia
    Al-Lawati, Hanaa
    Al-Adawi, Moza
    Al-Abri, Nadia
    Al-Dhahli, Buthaina
    Al-Adawi, Kawther
    [J]. APOPTOSIS, 2017, 22 (06) : 865 - 876
  • [3] Aoki T, 2023, ANN SURG ONCOL, V30, P3125, DOI 10.1245/s10434-022-12465-5
  • [4] Current evidence linking polyunsaturated fatty acids with cancer risk and progression
    Azrad, Maria
    Turgeon, Chelsea
    Demark-Wahnefried, Wendy
    [J]. FRONTIERS IN ONCOLOGY, 2013, 3
  • [5] Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER+ breast cancer
    Bacci, Marina
    Lorito, Nicla
    Smiriglia, Alfredo
    Subbiani, Angela
    Bonechi, Francesca
    Comito, Giuseppina
    Morriset, Ludivine
    El Botty, Rania
    Benelli, Matteo
    Lopez-Velazco, Joanna I.
    Caffarel, Maria M.
    Urruticoechea, Ander
    Sflomos, George
    Malorni, Luca
    Corsini, Michela
    Ippolito, Luigi
    Giannoni, Elisa
    Meattini, Icro
    Matafora, Vittoria
    Havas, Kristina
    Bachi, Angela
    Chiarugi, Paola
    Marangoni, Elisabetta
    Morandi, Andrea
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2024, 16 (736)
  • [6] Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
    Bartolacci, Caterina
    Andreani, Cristina
    Vale, Goncalo
    Berto, Stefano
    Melegari, Margherita
    Crouch, Anna Colleen
    Baluya, Dodge L.
    Kemble, George
    Hodges, Kurt
    Starrett, Jacqueline
    Politi, Katerina
    Starnes, Sandra L.
    Lorenzini, Daniele
    Raso, Maria Gabriela
    Soto, Luisa M. Solis
    Behrens, Carmen
    Kadara, Humam
    Gao, Boning
    Wistuba, Ignacio I.
    Minna, John D.
    McDonald, Jeffrey G.
    Scaglioni, Pier Paolo
    [J]. NATURE COMMUNICATIONS, 2022, 13 (01)
  • [7] Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer
    Bauerschlag, Dirk O.
    Maass, Nicolai
    Leonhardt, Peter
    Verburg, Frederik A.
    Pecks, Ulrich
    Zeppernick, Felix
    Morgenroth, Agnieszka
    Mottaghy, Felix M.
    Tolba, Rene
    Meinhold-Heerlein, Ivo
    Braeutigam, Karen
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2015, 13
  • [8] Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
    Bi, Junfeng
    Ichu, Taka-Aki
    Zanca, Ciro
    Yang, Huijun
    Zhang, Wei
    Gu, Yuchao
    Chowdhry, Sudhir
    Reed, Alex
    Ikegami, Shiro
    Turner, Kristen M.
    Zhang, Wenjing
    Villa, Genaro R.
    Wu, Sihan
    Quehenberger, Oswald
    Yong, William H.
    Kornblum, Harley, I
    Rich, Jeremy N.
    Cloughesy, Timothy F.
    Cavenee, Webster K.
    Furnari, Frank B.
    Cravatt, Benjamin F.
    Mischell, Paul S.
    [J]. CELL METABOLISM, 2019, 30 (03) : 525 - +
  • [9] Lipid metabolism in cancer: New perspectives and emerging mechanisms
    Broadfield, Lindsay A.
    Pane, Antonino Alejandro
    Talebi, Ali
    Swinnen, Johannes, V
    Fendt, Sarah-Maria
    [J]. DEVELOPMENTAL CELL, 2021, 56 (10) : 1363 - 1393
  • [10] Fatty acid synthase as a new therapeutic target for HER2-positive gastric cancer
    Castagnoli, Lorenzo
    Corso, Simona
    Franceschini, Alma
    Raimondi, Alessandra
    Bellomo, Sara Erika
    Dugo, Matteo
    Morano, Federica
    Prisciandaro, Michele
    Brich, Silvia
    Belfiore, Antonino
    Vingiani, Andrea
    Di Bartolomeo, Maria
    Pruneri, Giancarlo
    Tagliabue, Elda
    Giordano, Silvia
    Pietrantonio, Filippo
    Pupa, Serenella M.
    [J]. CELLULAR ONCOLOGY, 2023, 46 (03) : 661 - 676
123456789