Air pollution and respiratory health in patients with COPD: should we focus on indoor or outdoor sources?

被引：0
作者：
Evangelopoulos, Dimitris [1 ,2 ]
Zhang, Hanbin [1 ,2 ,3 ]
Chatzidiakou, Lia [4 ]
Walton, Heather [1 ,2 ]
Katsouyanni, Klea [1 ,2 ,5 ]
Jones, Roderic L. [4 ]
Quint, Jennifer K. [6 ,7 ]
Barratt, Benjamin [1 ,2 ]
机构：
[1] Imperial Coll London, MRC Ctr Environm & Hlth, Environm Res Grp, London, England
[2] Imperial Coll London, NIHR HPRU Environm Exposures & Hlth, London, England
[3] Univ Exeter, European Ctr Environm & Human Hlth, Exeter, Devon, England
[4] Univ Cambridge, Yusuf Hamied Dept Chem, Cambridge, England
[5] Natl & Kapodistrian Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
[6] Imperial Coll London, Natl Heart & Lung Inst, London, England
[7] Imperial Coll London, Sch Publ Hlth, London, England
来源：
THORAX | 2024年 / 79卷 / 12期
基金：
英国医学研究理事会;
关键词：
COPD epidemiology; COPD Exacerbations; Respiratory Measurement; PARTICULATE MATTER; PERSONAL EXPOSURE; LUNG-FUNCTION; AMBIENT; PANEL; COMPONENTS; CHILDREN;
D O I：
暂无
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Introduction While associations between ambient air pollution and respiratory health in chronic obstructive pulmonary disease (COPD) patients are well studied, little is known about individuals' personal exposure to pollution and associated health effects by source. Aim To separate measured total personal exposure into indoor-generated and outdoor-generated pollution and use these improved metrics in health models for establishing more reliable associations with exacerbations and respiratory symptoms. Methods We enrolled a panel of 76 patients with COPD and continuously measured their personal exposure to particles and gaseous pollutants and location with portable monitors for 134 days on average. We collected daily health information related to respiratory symptoms through diary cards and peak expiratory flow (PEF). Mixed-effects models were applied to quantify the relationship between total, indoor-generated and outdoor-generated personal exposures to pollutants with exacerbation and symptoms occurrence and PEF. Results Exposure to nitrogen dioxide from both indoor and outdoor sources was associated with exacerbations and respiratory symptoms. We observed an increase of 33% (22%-45%), 19% (12%-18%) and 12% (5%-20%) in the odds of exacerbation for an IQR increase in total, indoor-generated and outdoor-generated exposures. For carbon monoxide, health effects were mainly attributed to indoor-generated pollution. While no associations were observed for particulate matter(2.5) with COPD exacerbations, indoor-generated particles were associated with a significant decrease in PEF. Conclusions Indoor-generated and outdoor-generated pollution can deteriorate COPD patients' health. Policy-makers, physicians and patients with COPD should note the importance of decreasing exposure equally to both source types to decrease risk of exacerbation.
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收藏
页码：1116 / 1123
页数：8
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