CD47 as a potent target in cancer immunotherapy: A review

被引：1

作者：

Ahvati, Hiva ^{[1
]}

Roudi, Raheleh ^{[2
]}

Sobhani, Navid ^{[3
]}

Safari, Fatemeh ^{[4
]}

机构：

[1] Univ Tehran, Coll Sci, Sch Biol, Tehran, Iran

[2] Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, Stanford, CA 94305 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX USA

[4] Univ Guilan, Fac Sci, Dept Biol, Rasht, Iran

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2025年 / 1880卷 / 02期

关键词：

CD47; cancer therapy; Cellular pathways; Immunoglobulin superfamily; SIGNAL-REGULATORY PROTEIN; INTEGRIN-ASSOCIATED PROTEIN; ANTIGEN-PRESENTING CELLS; DENDRITIC CELLS; EWING SARCOMA; IMMUNE CHECKPOINT; TUMOR MICROENVIRONMENT; POOR-PROGNOSIS; SIRP-ALPHA; STEM-CELLS;

D O I：

10.1016/j.bbcan.2025.189294

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is the second-highest cause of death worldwide. Accordingly, finding new cancer treatments is of great interest to researchers. The current platforms to fight cancer such as chemotherapy, radiotherapy, and surgery are limited in efficacy, especially in the metastatic setting. In this war against cancer, the immune system is a powerful ally, but tumor cells often outsmart it through alternative pathways. Cluster of differentiation 47 (CD47), a protein that normally prevents healthy cells from being attacked by immune cells, is often overexpressed on cancer cells. This makes CD47 a prime target for immunotherapy. Blocking of CD47 has the potential to unleash the immune system's cell populations-such as myeloid cells, macrophages, and T cells-to allow the immune system to discover and destroy cancer cells more successfully. In this review, we aimed to provide the latest information and findings about the roles of CD47 in the regulation of various cellular pathways and, thus, the importance of CD47 as a potential target in cancer therapy.

引用

页数：19

共 204 条

[11] CD47 overexpression is associated with decreased neutrophil apoptosis/phagocytosis and poor prognosis in non-small-cell lung cancer patients [J].

Barrera, Lourdes ;

Montes-Servin, Edgar ;

Hernandez-Martinez, Juan-Manuel ;

de los Angeles Garcia-Vicente, Maria ;

Montes-Servin, Elizabeth ;

Herrera-Martinez, Marytere ;

Crispin, Jose C. ;

Borbolla-Escoboza, Jose Rafael ;

Arrieta, Oscar .

BRITISH JOURNAL OF CANCER, 2017, 117 (03) :385-397

[12] Syndecans in tumor cell adhesion and signaling [J].

Beauvais D.M. ;

Rapraeger A.C. .

Reproductive Biology and Endocrinology, 2 (1)

[13] Rectal Cancer, Version 6.2020 Featured Updates to the NCCN Guidelines [J].

Benson, Al B., III ;

Venook, Alan P. ;

Al-Hawary, Mahmoud M. ;

Arain, Mustafa A. ;

Chen, Yi-Jen ;

Ciombor, Kristen K. ;

Cohen, Stacey ;

Cooper, Harry S. ;

Deming, Dustin ;

Garrido-Laguna, Ignacio ;

Grem, Jean L. ;

Gunn, Andrew ;

Hoffe, Sarah ;

Hubbard, Joleen ;

Hunt, Steven ;

Kirilcuk, Natalie ;

Krishnamurthi, Smitha ;

Messersmith, Wells A. ;

Meyerhardt, Jeffrey ;

Miller, Eric D. ;

Mulcahy, Mary F. ;

Nurkin, Steven ;

Overman, Michael J. ;

Parikh, Aparna ;

Patel, Hitendra ;

Pedersen, Katrina ;

Saltz, Leonard ;

Schneider, Charles ;

Shibata, David ;

Skibber, John M. ;

Sofocleous, Constantinos T. ;

Stoffel, Elena M. ;

Stotsky-Himelfarb, Eden ;

Willett, Christopher G. ;

Johnson-Chilla, Alyse ;

Gurski, Lisa A. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2020, 18 (07) :807-815

[14] Blockade of the CD47/SIRPα checkpoint axis potentiates the macrophage-mediated antitumor efficacy of tafasitamab [J].

Biedermann, Alexander ;

Patra-Kneuer, Maria ;

Mougiakakos, Dimitrios ;

Buettner-Herold, Maike ;

Mangelberger-Eberl, Doris ;

Berges, Johannes ;

Kellner, Christian ;

Altmeyer, Sarah ;

Bittenbring, Jorg Thomas ;

Augsberger, Christian ;

Ilieva-Babinsky, Kristina ;

Haskamp, Stefan ;

Beier, Fabian ;

Lischer, Christopher ;

Vera, Julio ;

Luehrmann, Anja ;

Bertz, Simone ;

Voelkl, Simon ;

Jacobs, Benedikt ;

Steidl, Stefan ;

Mackensen, Andreas ;

Bruns, Heiko .

HAEMATOLOGICA, 2024, 109 (12) :3928-3940

[15] Drp1 mediates caspase-independent type III cell death in normal and leukemic cells [J].

Bras, Marlene ;

Yuste, Victor J. ;

Roue, Gael ;

Barbier, Sandrine ;

Sancho, Patricia ;

Virely, Clemence ;

Rubio, Manuel ;

Baudet, Sylvie ;

Esquerda, Josep E. ;

Merle-Beral, Helene ;

Sarfati, Marika ;

Susin, Santos A. .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (20) :7073-7088

[16] TIGIT blockade repolarizes AML-associated TIGIT+ M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis [J].

Brauneck, Franziska ;

Fischer, Brit ;

Witt, Marius ;

Muschhammer, Jana ;

Oelrich, Jennyfer ;

Avelar, Pedro Henrique da Costa ;

Tsoka, Sophia ;

Bullinger, Lars ;

Seubert, Elisa ;

Smit, Daniel J. ;

Bokemeyer, Carsten ;

Ackermann, Christin ;

Wellbrock, Jasmin ;

Haag, Friedrich ;

Fiedler, Walter .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (12)

[17] Blockade of Tigit on AML-Derived M2 Macrophages Results in Reprograming into the M1 Phenotype and Enhances CD47-Mediated Phagocytosis [J].

Brauneck, Franziska ;

Fischer, Brit ;

Wellbrock, Jasmin ;

Bokemeyer, Carsten ;

zur Wiesch, Julian Schulze ;

Haag, Friedrich ;

Ackermann, Christin ;

Fiedler, Walter .

BLOOD, 2021, 138

[18] Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family [J].

Brooke, G ;

Holbrook, JD ;

Brown, MH ;

Barclay, AN .

JOURNAL OF IMMUNOLOGY, 2004, 173 (04) :2562-2570

[19] INTEGRIN-ASSOCIATED PROTEIN - A 50-KD PLASMA-MEMBRANE ANTIGEN PHYSICALLY AND FUNCTIONALLY ASSOCIATED WITH INTEGRINS [J].

BROWN, E ;

HOOPER, L ;

HO, T ;

GRESHAM, H .

JOURNAL OF CELL BIOLOGY, 1990, 111 (06) :2785-2794

[20] Integrin-associated protein (CD47) and its ligands [J].

Brown, EJ ;

Frazier, WA .

TRENDS IN CELL BIOLOGY, 2001, 11 (03) :130-135

← 1 2 3 4 5 6 7 8 9 10 →