CAR-T cell therapy for the treatment of adult high-grade gliomas

被引：0
|
作者：
Park, Sangwoo [1 ,2 ]
Maus, Marcela V. [1 ,2 ]
Choi, Bryan D. [1 ,2 ,3 ]
机构：
[1] Massachusetts Gen Hosp, Canc Ctr, Cellular Immunotherapy Program, Boston, MA 02114 USA
[2] Harvard Med Sch, Boston, MA 02115 USA
[3] Massachusetts Gen Hosp, Brain Tumor Immunotherapy Lab, Dept Neurosurg, Boston, MA 02114 USA
来源：
NPJ PRECISION ONCOLOGY | 2024年 / 8卷 / 01期
关键词：
CHIMERIC ANTIGEN RECEPTORS; BLOOD-BRAIN-BARRIER; TGF-BETA; CANCER REGRESSION; IMMUNE-RESPONSES; NORMAL-TISSUES; TARGET; GLIOBLASTOMA; IMMUNOTHERAPY; ACTIVATION;
D O I：
10.1038/s41698-024-00753-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Treatment for malignant primary brain tumors, including glioblastoma, remains a significant challenge despite advances in therapy. CAR-T cell immunotherapy represents a promising alternative to conventional treatments. This review discusses the landscape of clinical trials for CAR-T cell therapy targeting brain tumors, highlighting key advancements like novel target antigens and combinatorial strategies designed to address tumor heterogeneity and immunosuppression, with the goal of improving outcomes for patients with these aggressive cancers.
引用
收藏
页数：12
相关论文
共 50 条
  • [41] Bevacizumab in the treatment of high-grade gliomas: an overview
    Saroj Kunnakkat
    Ashwatha Narayana
    Angiogenesis, 2011, 14 : 423 - 430
  • [42] High-Grade Gliomas
    Brett J. Theeler
    Morris D. Groves
    Current Treatment Options in Neurology, 2011, 13 : 386 - 399
  • [43] High-Grade Gliomas
    Theeler, Brett J.
    Groves, Morris D.
    CURRENT TREATMENT OPTIONS IN NEUROLOGY, 2011, 13 (04) : 386 - 399
  • [44] High-grade gliomas
    Haase, Jens
    SURGICAL NEUROLOGY, 2008, 70 (06): : 598 - 598
  • [45] CAR-T for the treatment of T cell malignancies
    DiPersio, John F.
    MEDICINE, 2019, 98 (26)
  • [46] Dendritic cell vaccines for high-grade gliomas
    Eagles, Matthew E.
    Nassiri, Farshad
    Badhiwala, Jetan H.
    Suppiah, Suganth
    Almenawer, Saleh A.
    Zadeh, Gelareh
    Aldape, Kenneth D.
    THERAPEUTICS AND CLINICAL RISK MANAGEMENT, 2018, 14 : 1299 - 1313
  • [47] CAR-T Cell Therapy for T-Cell Malignancies
    Testa, Ugo
    Chiusolo, Patrizia
    Pelosi, Elvira
    Castelli, Germana
    Leone, Giuseppe
    MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2024, 16 (01)
  • [48] CAR T-cell therapy for gliomas
    Song, Kun-Wei
    Scott, Brian J.
    CURRENT OPINION IN NEUROLOGY, 2024, 37 (06) : 672 - 681
  • [49] 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas
    K. Mahmoudi
    K. L. Garvey
    A. Bouras
    G. Cramer
    H. Stepp
    J. G. Jesu Raj
    D. Bozec
    T. M. Busch
    C. G. Hadjipanayis
    Journal of Neuro-Oncology, 2019, 141 : 595 - 607
  • [50] 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas
    Mahmoudi, K.
    Garvey, K. L.
    Bouras, A.
    Cramer, G.
    Stepp, H.
    Raj, J. G. Jesu
    Bozec, D.
    Busch, T. M.
    Hadjipanayis, C. G.
    JOURNAL OF NEURO-ONCOLOGY, 2019, 141 (03) : 595 - 607
12345