CAR-T cell therapy for the treatment of adult high-grade gliomas

被引：0
|
作者：
Park, Sangwoo [1 ,2 ]
Maus, Marcela V. [1 ,2 ]
Choi, Bryan D. [1 ,2 ,3 ]
机构：
[1] Massachusetts Gen Hosp, Canc Ctr, Cellular Immunotherapy Program, Boston, MA 02114 USA
[2] Harvard Med Sch, Boston, MA 02115 USA
[3] Massachusetts Gen Hosp, Brain Tumor Immunotherapy Lab, Dept Neurosurg, Boston, MA 02114 USA
来源：
NPJ PRECISION ONCOLOGY | 2024年 / 8卷 / 01期
关键词：
CHIMERIC ANTIGEN RECEPTORS; BLOOD-BRAIN-BARRIER; TGF-BETA; CANCER REGRESSION; IMMUNE-RESPONSES; NORMAL-TISSUES; TARGET; GLIOBLASTOMA; IMMUNOTHERAPY; ACTIVATION;
D O I：
10.1038/s41698-024-00753-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Treatment for malignant primary brain tumors, including glioblastoma, remains a significant challenge despite advances in therapy. CAR-T cell immunotherapy represents a promising alternative to conventional treatments. This review discusses the landscape of clinical trials for CAR-T cell therapy targeting brain tumors, highlighting key advancements like novel target antigens and combinatorial strategies designed to address tumor heterogeneity and immunosuppression, with the goal of improving outcomes for patients with these aggressive cancers.
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页数：12
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