Design and Synthesis of Novel 2,5-substituted Pyrido[4,3-d] Pyrimidines: In silico, Anti-diabetic and Anti-inflammatory Studies

Recently, there has been a growing interest in small drug molecules due to their ability to be easily customized with specific active sites of biomolecules. Sulfonyl-based compounds, in particular, have shown promise for various pharmacological applications and many of these drug molecules are now available in the commercial market. As a result, there is a significant increase in demand for small molecule compounds and their studies in pharmacological applications. In this context, we have presented a range of pyridopyrimidine derivatives functionalized with piperazine sulfonamides and various O-benzyl derivatives, characterized using various analytical tools. These compounds have demonstrated anti-diabetic and anti-inflammatory activities. The therapeutic activity of the compounds was also assessed through molecular docking studies, which supported the obtained results.