The use of 7T MRI in multiple sclerosis: review and consensus statement from the North American Imaging in Multiple Sclerosis Cooperative

被引：2

作者：

Harrison, Daniel M. ^{[1
,2
]}

Sati, Pascal ^{[3
]}

Klawiter, Eric C. ^{[4
]}

Narayanan, Sridar ^{[5
,6
]}

Bagnato, Francesca ^{[7
,8
]}

Beck, Erin S. ^{[9
]}

Barker, Peter ^{[10
]}

Calvi, Alberto ^{[11
]}

Cagol, Alessandro ^{[12
,13
,14
]}

Donadieu, Maxime ^{[15
]}

Duyn, Jeff ^{[16
]}

Granziera, Cristina ^{[12
,13
,17
]}

Henry, Roland G. ^{[18
]}

Huang, Susie Y. ^{[19
]}

Hoff, Michael N. ^{[20
]}

Mainero, Caterina ^{[19
]}

Ontaneda, Daniel ^{[21
]}

Reich, Daniel S. ^{[15
]}

Rudko, David A. ^{[5
,22
]}

Smith, Seth A. ^{[23
,24
]}

Trattnig, Siegfried ^{[25
]}

Zurawski, Jonathan ^{[26
]}

Bakshi, Rohit ^{[26
]}

Gauthier, Susan ^{[27
]}

Laule, Cornelia ^{[28
]}

机构：

[1] Univ Maryland, Dept Neurol, Sch Med, 110 South Paca St,3rd Floor, Baltimore, MD 21201 USA

[2] Baltimore VA Med Ctr, Baltimore, MD 21201 USA

[3] Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA 90048 USA

[4] Massachusetts Gen Hosp, Harvard Med Sch, Dept Neurol, Boston, MA 02114 USA

[5] Montreal Neurol Hosp & Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada

[6] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[7] Vanderbilt Univ, Dept Neurol, Neuroimmunol Div, Neuroimaging Unit,Med Ctr, Nashville, TN USA

[8] Tennessee Valley Healthcare Syst, GRECC, TN Valley Healthcare Syst, Nashville, TN 37212 USA

[9] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA

[10] Johns Hopkins Univ, Sch Med, Sch Med, Baltimore, MD 21205 USA

[11] Inst Invest Biomed August Pi i Sunyer FRCB IDIBAPS, Inst Invest Biomed August Pi I Sunyer FRCB IDIBAPS, Lab Expt Nefrol & Trasplantament LENIT, Barcelona, Spain

[12] Univ Basel, Univ Hosp Basel, Translat Imaging Neurol ThINk Basel, Dept Biomed Engn,Fac Med, Basel, Switzerland

[13] Univ Basel, Univ Hosp Basel, Res Ctr Clin Neuroimmunol, Basel, Switzerland

[14] Univ Genoa, Dept Hlth Sci, I-16132 Genoa, Italy

[15] Natl Inst Neurol Disorders & Stroke, NIH, Translat Neuroradiol Sect, Bethesda, MD 20892 USA

[16] NIH, Adv MRI Sect, Bethesda, MD 20892 USA

[17] Univ Hosp Basel, Dept Neurol, CH-4001 Basel, Switzerland

[18] Univ Calif San Francisco, UCSF Weill Inst Neurosci, Dept Neurol, San Francisco, CA 94158 USA

[19] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Harvard Med Sch, Dept Radiol, Charlestown, MA 02114 USA

[20] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94158 USA

[21] Cleveland Clin, Neurol Inst, Mellen Ctr Multiple Sclerosis, Cleveland, OH 44195 USA

[22] McGill Univ, Dept Biomed Engn, Montreal, PQ, Canada

[23] Vanderbilt Univ, Inst Imaging Sci, Nashville, TN 37212 USA

[24] Vanderbilt Univ, Dept Radiol & Radiol Sci, Nashville, TN 37212 USA

[25] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Vienna, Austria

[26] Brigham & Womens Hosp, Harvard Med Sch, Dept Neurol, Boston, MA 02115 USA

[27] Weill Cornell Med, Dept Neurol, New York, NY 10065 USA

[28] Univ British Columbia, Pathol & Lab Med, Int Collaborat Repair Discoveries ICORD, Vancouver, BC, Canada

来源：

BRAIN COMMUNICATIONS | 2024年 / 6卷 / 05期

基金：

加拿大自然科学与工程研究理事会; 瑞士国家科学基金会; 美国国家卫生研究院; 加拿大健康研究院;

关键词：

multiple sclerosis; magnetic resonance imaging; 7; Tesla; ultra-high field; CERVICAL-SPINAL CORD; CENTRAL VEIN SIGN; MAGNETIC-RESONANCE-SPECTROSCOPY; APPEARING WHITE-MATTER; VIVO DIFFUSION MRI; IRON RIM LESIONS; IN-VIVO; HUMAN BRAIN; INVERSION-RECOVERY; MS LESIONS;

D O I：

10.1093/braincomms/fcae359

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The use of ultra-high-field 7-Tesla (7T) MRI in multiple sclerosis (MS) research has grown significantly over the past two decades. With recent regulatory approvals of 7T scanners for clinical use in 2017 and 2020, the use of this technology for routine care is poised to continue to increase in the coming years. In this context, the North American Imaging in MS Cooperative (NAIMS) convened a workshop in February 2023 to review the previous and current use of 7T technology for MS research and potential future research and clinical applications. In this workshop, experts were tasked with reviewing the current literature and proposing a series of consensus statements, which were reviewed and approved by the NAIMS. In this review and consensus paper, we provide background on the use of 7T MRI in MS research, highlighting this technology's promise for identification and quantification of aspects of MS pathology that are more difficult to visualize with lower-field MRI, such as grey matter lesions, paramagnetic rim lesions, leptomeningeal enhancement and the central vein sign. We also review the promise of 7T MRI to study metabolic and functional changes to the brain in MS. The NAIMS provides a series of consensus statements regarding what is currently known about the use of 7T MRI in MS, and additional statements intended to provide guidance as to what work is necessary going forward to accelerate 7T MRI research in MS and translate this technology for use in clinical practice and clinical trials. This includes guidance on technical development, proposals for a universal acquisition protocol and suggestions for research geared towards assessing the utility of 7T MRI to improve MS diagnostics, prognostics and therapeutic efficacy monitoring. The NAIMS expects that this article will provide a roadmap for future use of 7T MRI in MS. In this article, the North American Imaging in Multiple Sclerosis Cooperative provides a review and consensus recommendations on 7-Tesla (7T) MRI for multiple sclerosis. The organization highlights the advantages of 7T MRI for visualization of pathology and urges translation for use in clinical care and clinical trials. Graphical Abstract

引用

页数：22

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