Visible-Light Promoted Iron-Catalyzed C-C Bond Cleavage of 1,2-Diols to Carbonyls

被引：0

作者：

Shu, Chunyan ^{[1
]}

Wang, Jing ^{[2
]}

Song, Junying ^{[2
]}

Ouyang, Yiwen ^{[2
]}

Xu, Jin-Bu ^{[2
]}

Gao, Feng ^{[2
]}

Li, Xiaohuan ^{[2
]}

机构：

[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Sch Chem, Chengdu 610031, Peoples R China

[2] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 15期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE CLEAVAGE; VICINAL DIOLS; GLYCOL-CLEAVAGE; ACIDS; SYSTEMS;

D O I：

10.1021/acs.orglett.4c04816

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple visible-light-promoted iron-catalyzed aerobic oxidative C-C bond cleavage of vicinal diols was developed. This reaction avoids the use of noble metal catalysts or specialized oxidants, yielding aldehydes and ketones without overoxidation. The new method works under air and at room temperature and features mild conditions and simple operation. Notably, the protocol is applicable for complex natural products, achieving the bioinspired conversion of the natural abundant diterpene oridonin to the natural rare enmein-type diterpene.

引用

页码：3813 / 3817

页数：5

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