Gender-/Sex-Specific Differences in Clinical Trials in Uro-Oncology

被引：0

作者：

Roesch, Marie Christine ^{[1
]}

Luetje, Lea Sophie ^{[1
]}

Gilbert, Nils ^{[1
]}

Merseburger, Axel Stuart ^{[1
]}

Osmonov, Daniar ^{[1
]}

机构：

[1] Univ Hosp Schleswig Holstein, Dept Urol, Campus Lubeck,Ratzeburger Allee 160, D-23566 Lubeck, Germany

来源：

AKTUELLE UROLOGIE | 2025年

关键词：

clinical trials; uro-oncology; gender; sex; enrollment in clinical trials; CANCER;

D O I：

10.1055/a-2510-9757

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Subgroup analyses in clinical trials sometimes reveal gender-/sex-dependent differences in cancer outcomes. However, drug approvals are rarely restricted to a specific sex or gender, and recommendations regarding dosage are rarely tailored accordingly. Furthermore, discrepancies exist between the gender-/sex-dependent enrollment rates in clinical trials and real-world incidence or mortality rates. This article highlights gender-/sex differences in clinical trials in uro-oncology.

引用

页数：4

共 19 条

[1] Assessment of gender representation in clinical trials leading to FDA approval for oncology therapeutics between 2014 and 2019: A systematic review-based cohort study [J].

Dymanus, Kyle A. ;

Butaney, Mohit ;

Magee, Diana E. ;

Hird, Amanda E. ;

Luckenbaugh, Amy N. ;

Ma, Merry W. ;

Hall, Mary E. ;

Huelster, Heather L. ;

Laviana, Aaron A. ;

Davis, Nancy B. ;

Terris, Martha K. ;

Klaassen, Zachary ;

Wallis, Christopher J. D. .

CANCER, 2021, 127 (17) :3156-3162

[2] Sex-specific Differences in Pharmacology [J].

Fender, Anke C. ;

Dobrev, Dobromir .

AKTUELLE KARDIOLOGIE, 2022, 11 (01) :62-66

[3]

International Agency for Research on Cancer World Health Organization, 2022, Cancer TodayAvailable

[4] Systematic Analysis of Sex-Linked Molecular Alterations and Therapies in Cancer [J].

Ma, Jonathan ;

Malladi, Sadhika ;

Beck, Andrew H. .

SCIENTIFIC REPORTS, 2016, 6

[5] Gender and cystectomy for bladder cancer: A high-volume tertiary urologic care center experience [J].

Mariotti, A. ;

Spatafora, P. ;

Sessa, F. ;

Saieva, C. ;

Galli, I. C. ;

Roviello, G. ;

Doni, L. ;

Zaccaro, C. ;

Bisegna, C. ;

Conte, F. L. ;

Mariottini, R. ;

Marzocco, A. ;

Masieri, L. ;

Vignolini, G. ;

Minervini, A. ;

Serni, S. ;

Carini, M. ;

Nesi, G. ;

Villari, D. .

EJSO, 2023, 49 (10)

[6] Sex Representation in Clinical Trials Associated withFDACancer Drug Approvals Differs Between Solid and Hematologic Malignancies [J].

Mendis, Shehara ;

Anand, Seerat ;

Karasinska, Joanna M. ;

Dasari, Arvind ;

Unger, Joseph M. ;

Gothwal, Anirudh ;

Ellis, Lee M. ;

Varadhachary, Gauri ;

Kopetz, Scott ;

Overman, Michael J. ;

Raghav, Kanwal ;

Loree, Jonathan M. .

ONCOLOGIST, 2021, 26 (02) :107-114

[7] Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma [J].

Motzer, R. J. ;

Tannir, N. M. ;

McDermott, D. F. ;

Frontera, O. Aren ;

Melichar, B. ;

Choueiri, T. K. ;

Plimack, Elizabeth R. ;

Barthelemy, P. ;

Porta, C. ;

George, S. ;

Powles, T. ;

Donskov, F. ;

Neiman, V. ;

Kollmannsberger, C. K. ;

Salman, P. ;

Gurney, H. ;

Hawkins, R. ;

Ravaud, A. ;

Grimm, M. -O. ;

Bracarda, S. ;

Barrios, C. H. ;

Tomita, Y. ;

Castellano, D. ;

Rini, B. I. ;

Chen, A. C. ;

Mekan, S. ;

McHenry, M. B. ;

Wind-Rotolo, M. ;

Doan, J. ;

Sharma, P. ;

Hammers, H. J. ;

Escudier, B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (14) :1277-1290

[8] Gender Disparity in Kidney Cancer Treatment: Women Are More Likely to Undergo Radical Excision of a Localized Renal Mass [J].

O'Malley, Rebecca L. ;

Underwood, Willie, III ;

Brewer, Katherine A. ;

Hayn, Matthew H. ;

Kim, Hyung L. ;

Mehedint, Diana C. ;

Safwat, Mohab W. ;

Huang, William C. ;

Schwaab, Thomas .

UROLOGY, 2013, 82 (05) :1065-1069

[9] Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma [J].

Powles, Thomas ;

Rosenberg, Jonathan E. ;

Sonpavde, Guru P. ;

Loriot, Yohann ;

Duran, Ignacio ;

Lee, Jae-Lyun ;

Matsubara, Nobuaki ;

Vulsteke, Christof ;

Castellano, Daniel ;

Wu, Chunzhang ;

Campbell, Mary ;

Matsangou, Maria ;

Petrylak, Daniel P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (12) :1125-1135

[10] Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma [J].

Powles, Thomas ;

Park, Se Hoon ;

Voog, Eric ;

Caserta, Claudia ;

Valderrama, Begona P. ;

Gurney, Howard ;

Kalofonos, Haralabos ;

Radulovic, Sinisa ;

Demey, Wim ;

Ullen, Anders ;

Loriot, Yohann ;

Sridhar, Srikala S. ;

Tsuchiya, Norihiko ;

Kopyltsov, Evgeny ;

Sternberg, Cora N. ;

Bellmunt, Joaquim ;

Aragon-Ching, Jeanny B. ;

Petrylak, Daniel P. ;

Laliberte, Robert ;

Wang, Jing ;

Huang, Bo ;

Davis, Craig ;

Fowst, Camilla ;

Costa, Nuno ;

Blake-Haskins, John A. ;

di Pietro, Alessandra ;

Grivas, Petros .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (13) :1218-1230

← 1 2 →