Comment on 'Histologic analysis of gonadal tissue in patients with Turner syndrome and Y chromosome material'

被引：2

作者：

Ozdemir-Sanci, Tuba ^{[1
,2
]}

机构：

[1] Ankara Yildirim Beyazit Univ, Fac Med, Dept Histol & Embryol, TR-06800 Ankara, Turkiye

[2] Ankara Yildirim Beyazit Univ, Yenimahalle Training & Res Hosp, TR-06370 Ankara, Turkiye

来源：

JOURNAL OF PEDIATRIC UROLOGY | 2025年 / 21卷 / 01期

基金：

美国国家卫生研究院;

关键词：

AUTOPHAGY;

D O I：

10.1016/j.jpurol.2024.07.016

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

This study investigates gonadal histology in individuals with Turner syndrome assigned female at birth and Y-chromosome material (TS+Y) who underwent prophylactic gonadectomy. Despite case reports suggesting spontaneous menarche and pregnancies in TS+Y, this research reveals the absence of germ cells, indicating low fertility likelihood. Germ cell neoplasia in-situ was present in some patients, emphasizing a non-negligible risk of cancer precursor. As no malignancies were found even in older individuals, the study challenges the immediate need for prophylactic gonadectomy upon TS+Y diagnosis. Limited fertility benefits are suggested, emphasizing the need for further research on optimal timing and criteria for the procedure. © 2024 Journal of Pediatric Urology Company

引用

页码：21 / 21

页数：1

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