How to facilitate the wider use of pharmacogenetic tests?*

被引:0
作者
Verstuyft, Celine [1 ]
Dewolf, Dominique [2 ]
Blin, Olivier [3 ]
Florentin, Virginie [4 ]
Mesnard, Laurent [5 ]
Chaumette, Boris [6 ]
Ayme-Dietrich, Estelle [7 ]
Raymond, Laure [8 ]
Lang, Marie [9 ]
Lamaziere, Antonin [10 ]
Allard, Beatrice [11 ]
Samelson, Laurence [12 ]
Lamezec, Liliane [13 ]
Loriot, Marie-Anne [14 ]
Le Bozec, Antoine [15 ]
Picard, Nicolas [16 ]
机构
[1] Univ Paris Saclay, Hop Univ Paris Saclay,Serv Genet Mol Pharmacogenet, AP HP,Inserm,UMR1018,CESP,MOODS Team,Fac Med, Hop Bicetre, F-94275 Le Kremlin Bicetre, France
[2] ThermoFisher Sci, F-91941 Villebon Sur Yvette, France
[3] Aix Marseille Univ, AP HM, Serv Pharmacol Clin & Pharmacosurveillance, UMR 1106,Inserm, F-13000 Marseille, France
[4] Roche SAS, Direct Med Personnalisee, F-92600 Boulogne Billancourt, France
[5] Hop Univ Paris Saclay, AP HP, Hop Tenon, Serv Nephrol,Inserm,UMR1155, F-75020 Paris, France
[6] Univ Paris Cite, Hop St Anne, Inst Psychiat & Neurosci Pairs IPNP, GHU Paris Psychiat & Neurosci,Inserm,U1266, F-75000 Paris, France
[7] Univ Strasbourg, Hop Univ Strasbourg, Lab Pharmacol & Toxicol Neurocardiovasc, UR7296, F-67091 Strasbourg, France
[8] Eurofins Biomnis, Lab Genet, F-69007 Lyon, France
[9] GCS CNCR, F-75014 Paris, France
[10] Sorbonne Univ, Hop St Antoine, AP HP, Dept Metab Clin,Ctr Rech St Antoine, F-75012 Paris, France
[11] Amgen Inc, Dept Affaires Med, F-92400 Courbevoie, France
[12] Keenturtle, Direct Med, F-69003 Lyon, France
[13] Bristol Myers Squibb, F-92500 Rueil Malmaison, France
[14] Univ Paris Cite, European Georges Pompidou Hosp, AP HP,Dept Clin Chem, Ctr Rech Cordeliers,Inserm,UMRS 1138, F-75000 Paris, France
[15] Hop Bicetre, AP HP, Serv Pharm, F-94270 Le Kremlin Bicetre, France
[16] CHU Limoges, Ctr Biol & Rech Sante Pharmacol Toxicol & Pharmaco, F-87042 Limoges, France
来源
THERAPIE | 2025年 / 80卷 / 01期
关键词
Pharmacogenetics; Personalized medicine; Genomics; Iatrogenesis; Artificial intelligence;
D O I
10.1016/j.therap.2024.11.010
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
4P medicine (personalized, preventive, predictive, and participatory) is experiencing a remarkable rise, and pharmacogenetics is an essential part of it. However, several obstacles are hindering its deployment. This round table brought together a group of experts to take stock of the situation, reflecting on ways to facilitate the prescription of these tests and the dissemination of the results on a national scale. The experts looked at the methods of prescribing and communicating pharmacogenetic data in the current situation as well as in the coming years, with the arrival of artificial intelligence software. The questions relating to the reimbursement of tests -- as topical as ever -- were also discussed, as this is a way to allow all patients to access these tests. Numerous recommendations have been formulated on these various points, aimed at facilitating prescription management for healthcare professionals, and ensuring the retention and use of the results throughout the patient's life. Finally, better patient information was recommended, as well as strengthening the involvement of healthcare professionals and industry stakeholders in this process, with insistence on the necessary training and commitment to ensure its success. (c) 2024 Published by Elsevier Masson SAS on behalf of Socie<acute accent>te<acute accent> franc,aise de pharmacologie et de the<acute accent>rapeutique.
引用
收藏
页码:103 / 112
页数:10
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