Update advances in anaplastic lymphoma kinase-positive non-small cell lung cancer treatment

被引：1

作者：

Munarriz, Beatriz E. Jimenez ^{[1
]}

Khan, Sam ^{[1
,2
]}

Li, Yuchen ^{[1
,3
,4
]}

Ghazali, Nadia ^{[1
]}

Liu, Geoffrey ^{[1
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Med Oncol Dept, Toronto, ON, Canada

[2] Univ Leicester, Div Med oncol, Leicester Canc Res, Leicester, England

[3] Queens Sch Med, Dept Oncol, Kingston, ON, Canada

[4] Canc Ctr Southeastern Ontario, Kingston, ON, Canada

来源：

CANCER | 2025年 / 131卷

关键词：

ALK detection; ALK diagnosis; ALK tyrosine kinase inhibitors; lung cancer; ALK REARRANGEMENTS; OPEN-LABEL; J-ALEX; CRIZOTINIB; FUSION; CHEMOTHERAPY; INHIBITOR; ALECTINIB; BRIGATINIB; MULTIPLEX;

D O I：

10.1002/cncr.35786

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer is the leading cause of cancer death worldwide. However, since the discovery and development of targeted therapies and immune checkpoint inhibitors, it has been a dramatically improved in survival outcomes and quality of life. Anaplastic lymphoma kinase (ALK) rearrangements occur in approximately 5% of patients with advanced non-small cell lung cancer (NSCLC), and the introduction of ALK tyrosine kinase inhibitors (TKIs) has changed the treatment paradigm. Although head-to-head randomized controlled trials for late generation inhibitors are lacking, the authors will review the current available options, treatments efficacy, safety profiles, ALK mechanisms of resistance, as well as new promising treatments in this field.

引用

页数：15

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