Phase-transfer-catalyzed enantioselective α-alkylation of aryl acetates

被引：0

作者：

Xiao, Yinuo ^{[1
]}

Li, Zhenpeng ^{[1
]}

Xu, Changming ^{[1
]}

机构：

[1] Lanzhou Jiaotong Univ, Sch Chem & Chem Engn, Lanzhou 730070, Peoples R China

来源：

TETRAHEDRON LETTERS | 2024年 / 152卷

基金：

中国国家自然科学基金;

关键词：

Asymmetric alpha-alkylation; Aryl acetates; Phase-transfer catalysis; Methylation; Naproxen;

D O I：

10.1016/j.tetlet.2024.155347

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chiral spirocyclic quaternary ammonium salt catalyzed asymmetric alkylation, especially methylation, of alpha-aryl esters possessing inherently poor reactivity under strong basic conditions has been developed, giving the target products with up to 94 % ee. This mild process was also applied to synthesize optically pure naproxen.

引用

页数：5

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