Exploring the association between atrial fibrillation and celiac disease: a comprehensive review

被引：0

作者：

Subedi, Rasish ^{[1
]}

Soulat, Amna ^{[2
]}

Rauf Butt, Samia ^{[7
]}

Mohan, Anmol ^{[3
]}

Danish Butt, Muhammad ^{[8
]}

Arwani, Suneel ^{[9
]}

Ahmed, Gulzar ^{[4
]}

Majumder, Koushik ^{[10
]}

Mohan Lal, Priyanka ^{[5
]}

Kumar, Vikash ^{[11
]}

Tejwaney, Usha ^{[12
]}

Ram, Nanik ^{[6
]}

Kumar, Sarwan ^{[13
]}

机构：

[1] Universal Coll Med Sci, Siddharthanagar, Nepal

[2] Ziauddin Med Coll, Karachi, Pakistan

[3] Karachi Med & Dent Coll, Karachi, Pakistan

[4] Dow Med Coll, Karachi, Pakistan

[5] Ziauddin Univ, Karachi, Pakistan

[6] Aga Khan Univ Hosp, Karachi, Pakistan

[7] Univ Coll Med & Dent, Faisalabad, Pakistan

[8] CMH Lahore Med Coll, Lahore, Pakistan

[9] Medway Maritime Hosp, Gillingham, England

[10] Chittagong Med Coll, Chittagong, Bangladesh

[11] Brooklyn Hosp Ctr, Brooklyn, NY USA

[12] Valley Hlth Syst, Ridgewood, NJ USA

[13] Wayne State Univ, Detroit, MI USA

来源：

ANNALS OF MEDICINE AND SURGERY | 2024年 / 86卷 / 12期

关键词：

atrial fibrillation; celiac disease; EUROPEAN-SOCIETY; RISK; THERAPY; GUIDELINES; DIAGNOSIS; TRANSGLUTAMINASE; PATHOPHYSIOLOGY; INFLAMMATION; ARRHYTHMIAS; RECURRENCE;

D O I：

10.1097/MS9.0000000000002259

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective:This paper aims to provide a comprehensive overview of the pathophysiology of atrial fibrillation (AF) and celiac disease (CD) individually while also exploring the emerging evidence of a potential association between the two conditions.Methods:The pathophysiology of AF, the most prevalent arrhythmia globally, and CD, an autoimmune condition triggered by gluten consumption, is examined. Genetic, structural, electrophysiological, and inflammatory factors contributing to their development are explored.Results:AF involves irregular atrial activity leading to electrical and structural remodeling of the atrium. CD is characterized by an immune response to gluten, primarily associated with HLA-DQ2 and HLA-DQ8 genetic mutations, resulting in damage to intestinal tissue. Emerging research suggests a link between AF and CD, possibly mediated through inflammation, fibrosis, and electromechanical delays in the atrium.Conclusion:Understanding the association between AF and CD carries significant clinical implications. Recognition of this relationship can assist in identifying individuals at higher risk for AF and inform proactive management strategies. Additionally, it underscores the importance of comprehensive care for CD patients, considering potential cardiac implications. Further research is warranted to elucidate precise mechanisms and explore potential therapeutic interventions targeting common pathways, opening avenues for enhanced patient care and future investigations.

引用

页码：7155 / 7163

页数：9

共 107 条

[81] LENGTH OF EXCITATION WAVE AND SUSCEPTIBILITY TO REENTRANT ATRIAL ARRHYTHMIAS IN NORMAL CONSCIOUS DOGS [J].