Antiviral Activity of Berbamine Against Influenza A Virus Infection

被引：0

作者：

Cho, Won-Kyung ^{[1
]}

Choi, Hee-Jeong ^{[1
]}

Ma, Jin Yeul ^{[1
]}

机构：

[1] Korea Inst Oriental Med, Korean Med KM Applicat Ctr, 70 Chemdanro, Daegu 41062, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

berbamine (BBM); anti-influenza A virus; hemagglutinin (HA); virucidal effect; POTENTIAL ENTRY INHIBITORS; CELLS;

D O I：

10.3390/ijms26062819

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Berbamine (BBM) is a bibenzyl isoquinoline present in the traditional Chinese herbal medicine Berberis amurensisis Rupr. The present study demonstrates that BBM exerts strong antiviral efficacy against influenza A virus (IAV) infection. We examined the anti-IAV effect of BBM using green fluorescent protein (GFP)-expressing influenza A and H1N1 IAV. The fluorescence microscopy, fluorescence-activated cell sorting analysis, and plaque assay showed that BBM significantly hinders IAV infection. The immunofluorescence analysis confirmed the anti-influenza activity of BBM. From the time-of-addition and hemagglutination inhibition results, it is elucidated that the antiviral effect of BBM is closely related to its inhibitory effect against viral binding and entry at an early infection stage. Our findings imply that BBM has the potential to be developed as a potent antiviral drug against influenza viral infection.

引用

页数：10