The efficacy of streptozotocin in managing pancreatic neuroendocrine neoplasms - A systematic review

被引：1

作者：

Arrivi, Giulia ^{[1
]}

Fazio, Nicola ^{[2
]}

Tafuto, Salvatore ^{[3
]}

Falconi, Massimo ^{[4
]}

Carnaghi, Carlo ^{[5
]}

Campana, Davide ^{[6
]}

Rinzivillo, Maria ^{[7
]}

Panzuto, Francesco ^{[7
]}

机构：

[1] Sapienza Univ Rome, St Andrea Univ Hosp, Dept Clin & Mol Med, Oncol Unit,ENETS Ctr Excellence, Rome, Italy

[2] European Inst Oncol, Div Gastrointestinal Med Oncol & Neuroendocrine Tu, IEO, IRCCS, Milan, Italy

[3] IRCCS Fdn G Pascale, Ist Nazl Tumori, Sarcomas & Rare Tumors Unit, I-80131 Naples, Italy

[4] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Pancreas Translat & Clin Res Ctr, Pancreat Surg Unit, Milan, Italy

[5] Humanitas Ist Clin Catanese, Med Oncol Unit, I-95045 Misterbianco, Catania, Italy

[6] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Med Oncol, IRCCS Azienda Osped Univ Bologna, Bologna, Italy

[7] Sapienza Univ Rome, St Andrea Univ Hosp, ENETS Ctr Excellence, Dept Surg Med Sci & Translat Med,Digest Dis Unit, Rome, Italy

来源：

CANCER TREATMENT REVIEWS | 2025年 / 134卷

关键词：

Neuroendocrine tumors; Guidelines; Streptozotocin; Alkylating agents; Chemotherapy; ANTITUMOR-ACTIVITY; ALKYLATING-AGENTS; ENDOCRINE TUMORS; CHEMOTHERAPY; TEMOZOLOMIDE; DOXORUBICIN; THERAPY; CAPECITABINE; FLUOROURACIL; 5-FLUOROURACIL;

D O I：

10.1016/j.ctrv.2025.102899

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic neuroendocrine tumors (pan-NETs) represent a highly heterogeneous and complex pathology, with therapeutic management and prognosis influenced by several biological and clinical characteristics. Chemotherapy, including regimens based on capecitabine and temozolomide (CAPTEM) or the combination of streptozotocin and 5-fluorouracil (STZ-5FU), is indicated for rapidly growing, symptomatic, or high-burden disease requiring swift cytoreduction. Historical studies provide scientific evidence for the STZ-5FU regimen, often retrospective and frequently analyzing small series. Despite these limitations, the efficacy of this treatment is well-established, and it is included in all guidelines as a therapeutic option. This systematic review aims to gather scientific evidence on using STZ-based chemotherapy to assess its real impact in managing well-differentiated metastatic or unresectable pan-NETs.

引用

页数：15

共 87 条

[1] Should temozolomide be used on the basis of O6-methylguanine DNA methyltransferase status in patients with advanced neuroendocrine tumors? A systematic review and meta-analysis [J].