Estimating Flow Direction of Circle of Willis Using Dynamic Arterial Spin-Labeling MR Angiography

被引：0

作者：

Zhang, Kaiyu ^{[1
]}

Akcicek, Halit ^{[5
]}

Shi, Gen ^{[6
,7
]}

Canton, Gador ^{[2
]}

Liu, Josh ^{[1
]}

Guo, Yin ^{[1
]}

Wang, Xin ^{[2
]}

Chen, Li ^{[2
]}

Pimentel, Kristi D. ^{[3
]}

Akcicek, Ebru Yaman ^{[5
]}

Tang, Xihe ^{[8
]}

Jin, Yongjian ^{[8
]}

Li, Xuesong ^{[9
]}

Balu, Niranjan ^{[3
]}

Hatsukami, Thomas S. ^{[4
]}

Mossa-Basha, Mahmud ^{[3
]}

Chen, Zhensen ^{[3
,10
,11
]}

Yuan, Chun ^{[1
,3
,5
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA USA

[2] Univ Washington, Dept Elect & Comp Engn, Seattle, WA USA

[3] Univ Washington, Dept Radiol, Seattle, WA USA

[4] Univ Washington, Dept Surg, Seattle, WA USA

[5] Univ Utah, Dept Radiol & Imaging Sci, Salt Lake City, UT USA

[6] Beihang Univ, Sch Engn Med, Beijing, Peoples R China

[7] Beihang Univ, Sch Biol Sci & Med Engn, Beijing, Peoples R China

[8] China Med Univ, Aviat Gen Hosp, Dept Neurosurg, Beijing, Peoples R China

[9] Beijing Inst Technol, Sch Comp Sci & Technol, Beijing, Peoples R China

[10] Fudan Univ, Key Lab Computat Neurosci & Brain Inspired Intelli, Minist Educ, Beijing, Peoples R China

[11] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai 200433, Peoples R China

来源：

AMERICAN JOURNAL OF NEURORADIOLOGY | 2024年 / 45卷 / 10期

基金：

美国国家卫生研究院;

关键词：

RECANALIZATION; HEMODYNAMICS; OCCLUSION;

D O I：

10.3174/ajnr.A8355

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BACKGROUND AND PURPOSE: The circle of Willis (COW) is a crucial mechanism for cerebral collateral circulation. This proof-of-concept study aims to develop and assess an analysis method to characterize the hemodynamics of the arterial segments in the COW by using arterial spin-labeling (ASL) based non-contrast-enhanced dynamic MR angiography (dMRA). MATERIALS AND METHODS: The developed analysis method uses a graph model, bootstrap strategy, and ensemble learning methodologies to determine the time curve shift from ASL dMRA to estimate the flow direction within the COW. The performance of the method was assessed on 52 subjects, by using the flow direction, either antegrade or retrograde, derived from 3D phase-contrast MR imaging as the reference. RESULTS: A total of 340 arterial segments in the COW were evaluated, among which 30 (8.8%) had retrograde flow according to 3D phase-contrast MRI. The ASL dMRA-based flow direction estimation has an accuracy, sensitivity, and specificity of 95.47%, 80%, and 96.34%, respectively. CONCLUSIONS: Using ASL dMRA and the developed image analysis method to estimate the flow direction in COW is feasible. This study provides a new method to assess the hemodynamics of the COW, which could be useful for the diagnosis and study of cerebrovascular diseases.

引用

页码：1419 / 1426

页数：8

共 38 条

[1] Applications of Graph Theory [J].