Ovarian cancer extracellular vesicle biomarkers

被引：1

作者：

Jamali, Zeinab ^{[1
]}

Razipour, Masoumeh ^{[1
]}

Zargar, Mahsa ^{[1
]}

Ghasemnejad-Berenji, Hojat ^{[2
]}

Akrami, Seyed Mohammad ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[2] Urmia Univ Med Sci, Clin Res Inst, Reprod Hlth Res Ctr, Orumiyeh, Iran

来源：

CLINICA CHIMICA ACTA | 2025年 / 565卷

关键词：

Ovarian cancer; Extracellular vesicle; Biomarker; Diagnosis; CEREBROSPINAL-FLUID BIOMARKERS; LIQUID BIOPSY; POTENTIAL BIOMARKER; DIAGNOSIS; EXOSOMES; RISK; ASCITES; DISEASE; CA125; WOMEN;

D O I：

10.1016/j.cca.2024.120011

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Ovarian cancer (OC) remains a significant women's health concern due to its high mortality rate and the challenges posed by late detection. Exploring novel biomarkers could lead to earlier, more specific diagnoses and improved survival rates for OC patients. This review focuses on biomarkers associated with extracellular vesicles (EVs) found in various proximal fluids, including urine, ascites, utero-tubal lavage fluid of OC patients. We highlight these proximal fluids as rich sources of potential biomarkers. The review explains the roles of EV biomarkers in ovarian cancer progression and discusses EV-related proteins and miRNAs as potential diagnostic or prognostic indicators and therapeutic targets. Finally, we highlighted the limitations of examining proximal fluids as sources of biomarkers and encourage researchers to proactively pursue innovative solutions to overcome these challenges.

引用

页数：12

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