New insight into targeting the DNA damage response in the treatment of glioblastoma

被引：0

作者：

Zhen, Tengfei ^{[1
]}

Sun, Tianyu ^{[1
]}

Xiong, Baichen ^{[1
]}

Liu, Hui ^{[2
]}

Wang, Lei ^{[1
]}

Chen, Yao ^{[3
]}

Sun, Haopeng ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Pharm, Nanjing 211198, Peoples R China

[2] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[3] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2024年 / 22卷 / 10期

关键词：

Glioblastoma; DNA damage response; Small molecule inhibitors; BLOOD-BRAIN-BARRIER; POLY(ADP-RIBOSE) POLYMERASE; HOMOLOGOUS RECOMBINATION; BREAST-CANCER; TEMOZOLOMIDE; INHIBITION; METHYLATION; REPAIR; ATM; CELLS;

D O I：

10.1016/S1875-5364(24)60694-1

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Glioblastoma (GBM) is the most common invasive malignant tumor in human brain tumors, representing the most severe grade of gliomas. Despite existing therapeutic approaches, patient prognosis remains dismal, necessitating the exploration of novel strategies to enhance treatment efficacy and extend survival. Due to the restrictive nature of the blood-brain barrier (BBB), small- molecule inhibitors are prioritized in the treatment of central nervous system tumors. Among these, DNA damage response (DDR) inhibitors have garnered significant attention due to their potent therapeutic potential across various malignancies. This review provides a detailed analysis of DDR pathways as therapeutic targets in GBM, summarizes recent advancements, therapeutic strategies, and ongoing clinical trials, and offers perspectives on future directions in this rapidly evolving field. The goal is to present a comprehensive outlook on the potential of DDR inhibitors in improving GBM management and outcomes.

引用

页码：869 / 886

页数：18

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